Clayton Springer
Overview
Explore the profile of Clayton Springer including associated specialties, affiliations and a list of published articles.
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20
Citations
213
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Recent Articles
1.
Thoma G, Miltz W, Waelchli R, Orain D, Spanka C, Decoret O, et al.
J Med Chem
. 2025 Feb;
68(4):4721-4742.
PMID: 39960261
Leukotriene C4 synthase (LTC4S) is a glutathione -transferase that mediates the biosynthesis of cysteinyl leukotriene C4 (LTC4). Cysteinyl leukotrienes (CysLTs) are lipid mediators that drive type 2 inflammation, bronchoconstriction, and...
2.
Brocklehurst C, Altmann E, Andre J, Bon C, Caya T, Davis H, et al.
J Med Chem
. 2024 Mar;
67(6):5111-5112.
PMID: 38471144
No abstract available.
3.
Brocklehurst C, Altmann E, Bon C, Davis H, Dunstan D, Ertl P, et al.
J Med Chem
. 2024 Jan;
67(3):2118-2128.
PMID: 38270627
We herein describe the development and application of a modular technology platform which incorporates recent advances in plate-based microscale chemistry, automated purification, in situ quantification, and robotic liquid handling to...
4.
Gotz J, Jackl M, Jindakun C, Marziale A, Andre J, Gosling D, et al.
Sci Adv
. 2023 Oct;
9(43):eadj2314.
PMID: 37889964
The generation of attractive scaffolds for drug discovery efforts requires the expeditious synthesis of diverse analogues from readily available building blocks. This endeavor necessitates a trade-off between diversity and ease...
5.
Tria G, Abrams T, Baird J, Burks H, Firestone B, Gaither L, et al.
J Med Chem
. 2018 Mar;
61(7):2837-2864.
PMID: 29562737
In breast cancer, estrogen receptor alpha (ERα) positive cancer accounts for approximately 74% of all diagnoses, and in these settings, it is a primary driver of cell proliferation. Treatment of...
6.
Pearlstein R, MacCannell K, Erdemli G, Yeola S, Helmlinger G, Hu Q, et al.
Curr Top Med Chem
. 2016 Mar;
16(16):1792-818.
PMID: 26975508
Blockade of the hERG potassium channel prolongs the ventricular action potential (AP) and QT interval, and triggers early after depolarizations (EADs) and torsade de pointes (TdP) arrhythmia. Opinions differ as...
7.
Stiefl N, Gedeck P, Chin D, Hunt P, Lindvall M, Spiegel K, et al.
J Chem Inf Model
. 2015 Mar;
55(4):896-908.
PMID: 25816021
Communication of data and ideas within a medicinal chemistry project on a global as well as local level is a crucial aspect in the drug design cycle. Over a time...
8.
Toure B, Miller-Moslin K, Yusuff N, Perez L, Dore M, Joud C, et al.
ACS Med Chem Lett
. 2014 Jun;
4(2):186-90.
PMID: 24900652
Overexpression of the antiapoptotic members of the Bcl-2 family of proteins is commonly associated with cancer cell survival and resistance to chemotherapeutics. Here, we describe the structure-based optimization of a...
9.
Yusuff N, Dore M, Joud C, Visser M, Springer C, Xie X, et al.
ACS Med Chem Lett
. 2014 Jun;
3(7):579-83.
PMID: 24900514
The discovery of new Bcl-2 protein-protein interaction antagonists is described. We replaced the northern fragment of ABT737 (π-π stacking interactions) with structurally simplified hydrophobic cage structures with much reduced conformational...
10.
Beck J, Springer C
J Chem Inf Model
. 2014 Mar;
54(4):1226-34.
PMID: 24605924
The concepts of activity cliffs and matched molecular pairs (MMP) are recent paradigms for analysis of data sets to identify structural changes that may be used to modify the potency...