Claus Storgaard Sorensen
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Explore the profile of Claus Storgaard Sorensen including associated specialties, affiliations and a list of published articles.
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52
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3215
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Recent Articles
1.
Jiang X, Mohapatra P, Rossing M, Zheng W, Zbodakova O, Thatte J, et al.
Cells
. 2025 Jan;
14(1.
PMID: 39791760
Nuclear actin polymerization was reported to control different nuclear processes, but its regulation is poorly understood. Here, we show that N-WASP can trigger the formation of nuclear N-WASP/F-actin nodules. While...
2.
Tuppurainen H, Laurila N, Natynki M, Eshraghi L, Tervasmaki A, Erichsen L, et al.
Cell Mol Life Sci
. 2024 Apr;
81(1):173.
PMID: 38597967
Heterozygous mutations in any of three major genes, BRCA1, BRCA2 and PALB2, are associated with high-risk hereditary breast cancer susceptibility frequently seen as familial disease clustering. PALB2 is a key...
3.
Piotrowski K, Blasco L, Samsoe-Petersen J, Eefsen R, Illemann M, Oria V, et al.
Cancer Gene Ther
. 2023 Jul;
30(10):1369-1381.
PMID: 37495855
Radiotherapy is one of the most common cancer treatments, yet, some patients require high doses to respond. Therefore, the development of new strategies leans toward personalizing therapy to avoid unnecessary...
4.
Benada J, Bulanova D, Azzoni V, Petrosius V, Ghazanfar S, Wennerberg K, et al.
NAR Cancer
. 2023 Jun;
5(3):zcad029.
PMID: 37325550
Ovarian cancer is driven by genetic alterations that necessitate protective DNA damage and replication stress responses through cell cycle control and genome maintenance. This creates specific vulnerabilities that may be...
5.
Green A, Marttila P, Kiweler N, Chalkiadaki C, Wiita E, Cookson V, et al.
Nat Metab
. 2023 Apr;
5(4):642-659.
PMID: 37012496
Cancer cells fuel their increased need for nucleotide supply by upregulating one-carbon (1C) metabolism, including the enzymes methylenetetrahydrofolate dehydrogenase-cyclohydrolase 1 and 2 (MTHFD1 and MTHFD2). TH9619 is a potent inhibitor...
6.
Petrosius V, Benada J, Nielsen O, Schoof E, Sorensen C
iScience
. 2023 Jan;
26(1):105806.
PMID: 36632060
Wee1-like protein kinase (WEE1) restrains activities of cyclin-dependent kinases (CDKs) in S and G2 phase. Inhibition of WEE1 evokes drastic increase in CDK activity, which perturbs replication dynamics and compromises...
7.
Niu Y, Ferreira Azevedo C, Li X, Kamali E, Nielsen O, Sorensen C, et al.
Nat Genet
. 2022 Dec;
54(12):1983-1993.
PMID: 36471068
Determining the functional role of thousands of genetic sequence variants (mutations) associated with genetic diseases is a major challenge. Here we present clustered regularly interspaced short palindromic repeat (CRISPR)-Select, CRISPR-Select...
8.
Maynard S, Hall A, Galanos P, Rizza S, Yamamoto T, Gram H, et al.
Nucleic Acids Res
. 2022 Sep;
50(17):9948-9965.
PMID: 36099415
Mutations in the lamin A/C gene (LMNA) cause laminopathies such as the premature aging Hutchinson Gilford progeria syndrome (HGPS) and altered lamin A/C levels are found in diverse malignancies. The...
9.
Galanos P, Pappas G, Polyzos A, Kotsinas A, Svolaki I, Giakoumakis N, et al.
Genome Biol
. 2022 Apr;
23(1):107.
PMID: 35484586
No abstract available.
10.
Elbaek C, Petrosius V, Benada J, Erichsen L, Damgaard R, Sorensen C
Cell Rep
. 2022 Jan;
38(3):110261.
PMID: 35045293
Cellular feedback systems ensure genome maintenance during DNA replication. When replication forks stall, newly replicated DNA is protected by pathways that limit excessive DNA nuclease attacks. Here we show that...