Claudia Sagheddu
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Explore the profile of Claudia Sagheddu including associated specialties, affiliations and a list of published articles.
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34
Citations
632
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Recent Articles
1.
Aroni S, Sagheddu C, Pistis M, Muntoni A
Cells
. 2024 Nov;
13(21.
PMID: 39513916
The mesolimbic reward system originating from dopamine neurons in the ventral tegmental area (VTA) of the midbrain shows a profound reduction in function during cannabinoid withdrawal. This condition may underlie...
2.
Barti B, Dudok B, Kenesei K, Zoldi M, Miczan V, Balla G, et al.
Sci Adv
. 2024 May;
10(22):eado0077.
PMID: 38809980
While our understanding of the nanoscale architecture of anterograde synaptic transmission is rapidly expanding, the qualitative and quantitative molecular principles underlying distinct mechanisms of retrograde synaptic communication remain elusive. We...
3.
Sagheddu C, Stojanovic T, Kouhnavardi S, Savchenko A, Hussein A, Pistis M, et al.
Front Aging Neurosci
. 2024 Mar;
16:1357347.
PMID: 38469164
Introduction: Deterioration of cognitive functions is commonly associated with aging, although there is wide variation in the onset and manifestation. Albeit heterogeneity in age-related cognitive decline has been studied at...
4.
Mostallino R, Santoni M, Sagheddu C, Serra V, Orru V, Pistis M, et al.
Eur J Pharmacol
. 2023 Nov;
961:176172.
PMID: 37939988
Maternal infections during pregnancy may increase the risk of psychiatric disorders in offspring. We recently demonstrated that activation of peroxisome proliferator-activate receptor-α (PPARα), with the clinically available agonist fenofibrate (FEN),...
5.
Sagheddu C, Cancedda E, Bagheri F, Kalaba P, Muntoni A, Lubec J, et al.
Int J Neuropsychopharmacol
. 2023 Sep;
26(11):784-795.
PMID: 37725477
Background: Dopamine plays a key role in several physiological functions such as motor control, learning and memory, and motivation and reward. The atypical dopamine transporter inhibitor S,S stereoisomer of 5-(((S)-((S)-(3-bromophenyl)(phenyl)methyl)sulfinyl)methyl)thiazole...
6.
Sagheddu C, Devoto P, Aroni S, Saba P, Pistis M, Gessa G
Front Pharmacol
. 2023 Sep;
14:1238115.
PMID: 37680715
Experimental and clinical evidence indicates a deficit of release and function of dopamine in schizophrenia and suggests that α-adrenoceptor antagonists rescue dopamine deficit and improve the antipsychotic efficacy of D-receptor...
7.
Lubec J, Hussein A, Kalaba P, Feyissa D, Arias-Sandoval E, Cybulska-Klosowicz A, et al.
Biomolecules
. 2023 Mar;
13(3).
PMID: 36979402
The worldwide increase in cognitive decline, both in aging and with psychiatric disorders, warrants a search for pharmacological treatment. Although dopaminergic treatment approaches represent a major step forward, current dopamine...
8.
Santoni M, Sagheddu C, Serra V, Mostallino R, Castelli M, Pisano F, et al.
Brain Behav Immun
. 2023 Feb;
109:271-284.
PMID: 36746342
Prenatal infections can increase the risk of developing psychiatric disorders such as schizophrenia in the offspring, especially when combined with other postnatal insults. Here, we tested, in a rat model...
9.
Palmas M, Etzi M, Pisanu A, Camoglio C, Sagheddu C, Santoni M, et al.
Cells
. 2022 Sep;
11(17).
PMID: 36078036
Parkinson's disease (PD) is a complex pathology causing a plethora of non-motor symptoms besides classical motor impairments, including cognitive disturbances. Recent studies in the PD human brain have reported microgliosis...
10.
Kouhnavardi S, Ecevitoglu A, Dragacevic V, Sanna F, Arias-Sandoval E, Kalaba P, et al.
Biomolecules
. 2022 Jul;
12(7).
PMID: 35883437
Dopamine (DA), the most abundant human brain catecholaminergic neurotransmitter, modulates key behavioral and neurological processes in young and senescent brains, including motricity, sleep, attention, emotion, learning and memory, and social...