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» Authors » Claudia Rheinheimer

Claudia Rheinheimer

Explore the profile of Claudia Rheinheimer including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 12
Citations 364
Followers 0
Related Specialties
Allergy & Immunology
Biochemistry
Microbiology
Top 10 Co-Authors
Andreas Klos
Robert Laudeley
Martin Kohn
Christian Lanfermann
Silke Glage
Kay Johswich
Pavel Dutow
Beate Fehlhaber
Myriam Schaefer
Jessica Thalmann
Published In
Front Immunol
J Biol Chem
Vaccines (Basel)
Eur J Immunol
Inflamm Bowel Dis
Affiliations
Soon will be listed here.
Recent Articles
1.
Cross-Serovar Protection during Experimental Lung Reinfection in Mice
Lanfermann C, Kohn M, Laudeley R, Rheinheimer C, Klos A
Vaccines (Basel) . 2021 Aug; 9(8). PMID: 34451996
causes most bacterial sexually transmitted diseases worldwide. Different major outer membrane proteins (MOMPs) define various serovars of this intracellular pathogen: In women, D to L3 can cause urethritis, cervicitis, salpingitis,...
2.
Prophylactic Multi-Subunit Vaccine against In Vivo Evaluation in Mice
Lanfermann C, Wintgens S, Ebensen T, Kohn M, Laudeley R, Schulze K, et al.
Vaccines (Basel) . 2021 Jul; 9(6). PMID: 34204170
is the most frequent sexually-transmitted disease-causing bacterium. Urogenital serovars of this intracellular pathogen lead to urethritis and cervicitis. Ascending infections result in pelvic inflammatory disease, salpingitis, and oophoritis. One of...
3.
Complement and : Early Complement-Dependent Events Are Important for DC Migration and Protection During Mouse Lung Infection
Kohn M, Lanfermann C, Laudeley R, Glage S, Rheinheimer C, Klos A
Front Immunol . 2021 Mar; 12:580594. PMID: 33767691
The zoonotic intracellular bacterium causes life-threatening pneumonia in humans. During mouse lung infection, complement factor C3 and the anaphylatoxin C3a augment protection against by a so far unknown mechanism. To...
4.
Complement and : Non-Myeloid-Derived C3 Predominantly Induces Protective Adaptive Immune Responses in Mouse Lung Infection
Kohn M, Lanfermann C, Laudeley R, Glage S, Rheinheimer C, Klos A
Front Immunol . 2021 Mar; 12:626627. PMID: 33746963
Recent advances in complement research have revolutionized our understanding of its role in immune responses. The immunomodulatory features of complement in infections by intracellular pathogens, e.g., viruses, are attracting increasing...
5.
T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells
Arbore G, West E, Spolski R, Robertson A, Klos A, Rheinheimer C, et al.
Science . 2016 Jun; 352(6292):aad1210. PMID: 27313051
The NLRP3 inflammasome controls interleukin-1β maturation in antigen-presenting cells, but a direct role for NLRP3 in human adaptive immune cells has not been described. We found that the NLRP3 inflammasome...
6.
An optimized, fast-to-perform mouse lung infection model with the human pathogen Chlamydia trachomatis for in vivo screening of antibiotics, vaccine candidates and modified host-pathogen interactions
Dutow P, Wask L, Bothe M, Fehlhaber B, Laudeley R, Rheinheimer C, et al.
Pathog Dis . 2015 Dec; 74(2). PMID: 26676260
Chlamydia trachomatis causes sexually transmitted diseases with infertility, pelvic inflammatory disease and neonatal pneumonia as complications. The duration of urogenital mouse models with the strict mouse pathogen C. muridarum addressing...
7.
The complement C3a receptor is critical in defense against Chlamydia psittaci in mouse lung infection and required for antibody and optimal T cell response
Dutow P, Fehlhaber B, Bode J, Laudeley R, Rheinheimer C, Glage S, et al.
J Infect Dis . 2013 Nov; 209(8):1269-78. PMID: 24273177
Background: The complement system protects against extracellular pathogens and links innate and adaptive immunity. In this study, we investigated the anaphylatoxin C3a receptor (C3aR) in Chlamydia psittaci lung infection and...
8.
Role of the C5a receptor (C5aR) in acute and chronic dextran sulfate-induced models of inflammatory bowel disease
Johswich K, Martin M, Bleich A, Kracht M, Dittrich-Breiholz O, Gessner J, et al.
Inflamm Bowel Dis . 2009 Aug; 15(12):1812-23. PMID: 19714742
Background: Inflammatory bowel disease (IBD) is a critical public health issue; more and more people are affected, but treatment options remain limited. Complement activation and the anaphylatoxin C5a have been...
9.
Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines
Johswich K, Martin M, Thalmann J, Rheinheimer C, Monk P, Klos A
J Biol Chem . 2006 Oct; 281(51):39088-95. PMID: 17068344
During complement activation the pro-inflammatory anaphylatoxins C3a and C5a are generated, which interact with the C3a receptor and C5a receptor (CD88), respectively. C5a and its degradation product C5a-des-Arg(74) also bind...
10.
The transcription factors AP-1 and Ets are regulators of C3a receptor expression
Schaefer M, Konrad S, Thalmann J, Rheinheimer C, Johswich K, Sohns B, et al.
J Biol Chem . 2005 Oct; 280(51):42113-23. PMID: 16253992
The anaphylatoxin C3a is a proinflammatory mediator generated during complement activation. The tight control of C3a receptor (C3aR) expression is crucial for the regulation of anaphylatoxin-mediated effects. Key factors regulating...