Claudia E Murar
Overview
Explore the profile of Claudia E Murar including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
55
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Recent Articles
1.
Matabaro E, Kaspar H, Dahlin P, Bader D, Murar C, Staubli F, et al.
Sci Rep
. 2022 Oct;
12(1):17021.
PMID: 36220874
No abstract available.
2.
Matabaro E, Kaspar H, Dahlin P, Bader D, Murar C, Staubli F, et al.
Sci Rep
. 2021 Jun;
11(1):12656.
PMID: 34112888
No abstract available.
3.
Matabaro E, Kaspar H, Dahlin P, Bader D, Murar C, Staubli F, et al.
Sci Rep
. 2021 Feb;
11(1):3541.
PMID: 33574430
Backbone N-methylation and macrocyclization improve the pharmacological properties of peptides by enhancing their proteolytic stability, membrane permeability and target selectivity. Borosins are backbone N-methylated peptide macrocycles derived from a precursor...
4.
Murar C, Ninomiya M, Shimura S, Karakus U, Boyman O, Bode J
Angew Chem Int Ed Engl
. 2020 Feb;
59(22):8425-8429.
PMID: 32032465
Chemical protein synthesis allows the construction of well-defined structural variations and facilitates the development of deeper understanding of protein structure-function relationships and new protein engineering strategies. Herein, we report the...
5.
Boehm J, Davis R, Murar C, Li T, McCleland B, Dong S, et al.
Bioorg Med Chem
. 2019 Jan;
27(4):579-588.
PMID: 30626555
The antioxidant natural product sulforaphane (SFN) is an oil with poor aqueous and thermal stability. Recent work with SFN has sought to optimize methods of formulation for oral and topical...
6.
Murar C, Harmand T, Bode J
Bioorg Med Chem
. 2017 Jul;
25(18):4996-5001.
PMID: 28662960
We describe a new route for the synthesis of (S)-N-Boc-5-oxaproline. This building block is a key element for the chemical synthesis of proteins with the α-ketoacid-hydroxylamine (KAHA) ligation. The new...
7.
Harmand T, Murar C, Bode J
Nat Protoc
. 2016 May;
11(6):1130-47.
PMID: 27227514
Total chemical synthesis of proteins allows researchers to custom design proteins without the complex molecular biology that is required to insert non-natural amino acids or the biocontamination that arises from...
8.
Murar C, Thuaud F, Bode J
J Am Chem Soc
. 2014 Dec;
136(52):18140-8.
PMID: 25474323
Aldehydes are widely recognized as valuable synthetic handles for the chemoselective manipulation of peptides and proteins. In this report, we show that peptides and small proteins containing the aspartic acid...
9.
Harmand T, Murar C, Bode J
Curr Opin Chem Biol
. 2014 Oct;
22:115-21.
PMID: 25299573
The identification of fast, chemoselective bond-forming reactions is one of the major contemporary challenges in chemistry. The requirements of the native chemical ligation - an N-terminal cysteine and C-terminal thioesters...