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» Authors » Clark M Whitehead

Clark M Whitehead

Explore the profile of Clark M Whitehead including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 397
Followers 0
Related Specialties
Oncology
Biochemistry
Pharmacology
Top 10 Co-Authors
Rifat Pamukcu
Hector Alila
Gary Piazza
W Joseph Thompson
Tom L M Zhao
Daniel C Chan
Paul A Bunn Jr
Barbara Helfrich
Douglas P Malinowski
Keith A Earle
Published In
Proc Natl Acad Sci U S A
Biochem Pharmacol
J Immunol Methods
Semin Oncol
Mol Cancer Ther
Affiliations
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Recent Articles
1.
Characterization and clinical validation of MCM2 and TOP2A monoclonal antibodies in the BD ProEx™ C assay: An immunoassay which detects aberrant S-phase induction in cervical tissue
Dixon E, King L, Nelson R, Simkins S, Knapp S, Brough G, et al.
J Immunol Methods . 2017 Jan; 442:35-41. PMID: 28093271
Background: The Papanicolaou (Pap) screen has been successful in reducing cervical cancer; but exhibits low sensitivity when detecting cervical dysplasia. Use of molecular biomarkers in Pap tests may improve diagnostic...
2.
Evaluation of biomarker panels for early stage ovarian cancer detection and monitoring for disease recurrence
Havrilesky L, Whitehead C, Rubatt J, Cheek R, Groelke J, He Q, et al.
Gynecol Oncol . 2008 Jul; 110(3):374-82. PMID: 18584856
Objective: To determine the utility of novel combinations of biomarkers, using both a one-step and two-step assay format, to distinguish serum of early ovarian cancer patients from that of healthy...
3.
Exisulind-induced apoptosis in a non-small cell lung cancer orthotopic lung tumor model augments docetaxel treatment and contributes to increased survival
Whitehead C, Earle K, Fetter J, Xu S, Hartman T, Chan D, et al.
Mol Cancer Ther . 2003 May; 2(5):479-88. PMID: 12748310
We reported previously a significant increase in survival of nude rats harboring orthotopic A549 human non-small cell lung cancer tumors after treatment with a combination of exisulind (Sulindac Sulfone) and...
4.
Pro-apoptotic actions of exisulind and CP461 in SW480 colon tumor cells involve beta-catenin and cyclin D1 down-regulation
Li H, Liu L, David M, Whitehead C, Chen M, Fetter J, et al.
Biochem Pharmacol . 2002 Oct; 64(9):1325-36. PMID: 12392815
Exisulind and its analogues are inhibitors of cyclic GMP phosphodiesterases (PDEs) that have been shown to activate and induce protein kinase G, resulting in the induction of apoptosis in colon...
5.
Exisulind in combination with docetaxel inhibits growth and metastasis of human lung cancer and prolongs survival in athymic nude rats with orthotopic lung tumors
Chan D, Earle K, Zhao T, Helfrich B, Zeng C, Baron A, et al.
Clin Cancer Res . 2002 Mar; 8(3):904-12. PMID: 11895925
Docetaxel, a semisynthetic taxane, improves the survival of stage IIIB and IV non-small cell lung cancer patients. However, the 5-year survival remains poor, and few patients experience a complete remission....
6.
Preclinical and clinical studies of docetaxel and exisulind in the treatment of human lung cancer
Bunn Jr P, Chan D, Earle K, Zhao T, Helfrich B, Kelly K, et al.
Semin Oncol . 2002 Mar; 29(1 Suppl 4):87-94. PMID: 11894018
Lung cancer is the leading cause of cancer death in the United States. The majority of patients with non-small cell lung cancers present with inoperable disease because of the presence...
7.
Centrosome amplification drives chromosomal instability in breast tumor development
Lingle W, Barrett S, Negron V, DAssoro A, Boeneman K, Liu W, et al.
Proc Natl Acad Sci U S A . 2002 Feb; 99(4):1978-83. PMID: 11830638
Earlier studies of invasive breast tumors have shown that 60-80% are aneuploid and approximately 80% exhibit amplified centrosomes. In this study, we investigated the relationship of centrosome amplification with aneuploidy,...