Clark D Jeffries
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Explore the profile of Clark D Jeffries including associated specialties, affiliations and a list of published articles.
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20
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941
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Recent Articles
1.
Jeffries C, Ford J, Tilson J, Perkins D, Bost D, Filer D, et al.
Sci Rep
. 2022 Apr;
12(1):5440.
PMID: 35361850
Regularized regression analysis is a mature analytic approach to identify weighted sums of variables predicting outcomes. We present a novel Coarse Approximation Linear Function (CALF) to frugally select important predictors...
2.
Filer D, Kuo F, Brandt A, Tilley C, Mieczkowski P, Berg J, et al.
BMC Bioinformatics
. 2021 Jul;
22(1):374.
PMID: 34284719
Background: As exome sequencing (ES) integrates into clinical practice, we should make every effort to utilize all information generated. Copy-number variation can lead to Mendelian disorders, but small copy-number variants...
3.
Albin K, Albin C, Jeffries C, Perkins D
J Adolesc Health
. 2021 Apr;
69(3):457-464.
PMID: 33846053
Purpose: Psychotic disorders develop during mid-adolescence through early adulthood, with the initial few months a "critical period" offering the greatest promise for recovery. However, the duration of untreated psychosis is...
4.
Perkins D, Jeffries C, Do K
Biol Psychiatry
. 2020 Jun;
88(4):326-336.
PMID: 32560962
Converging evidence implicates redox dysregulation as a pathological mechanism driving the emergence of psychosis. Increased oxidative damage and decreased capacity of intracellular redox modulatory systems are consistent findings in persons...
5.
Perkins D, Olde Loohuis L, Barbee J, Ford J, Jeffries C, Addington J, et al.
Am J Psychiatry
. 2019 Nov;
177(2):155-163.
PMID: 31711302
Objective: The 2-year risk of psychosis in persons who meet research criteria for a high-risk syndrome is about 15%-25%; improvements in risk prediction accuracy would benefit the development and implementation...
6.
Ward H, Lawson M, Addington J, Bearden C, Cadenhead K, Cannon T, et al.
Early Interv Psychiatry
. 2018 Oct;
13(5):1173-1181.
PMID: 30362261
Aim: To evaluate the role of tobacco use in the development of psychosis in individuals at clinical high risk. Method: The North American Prodrome Longitudinal Study is a 2-year multi-site...
7.
Jeffries C, Perkins D, Fournier M, Do K, Cuenod M, Khadimallah I, et al.
Transl Psychiatry
. 2018 Jun;
8(1):112.
PMID: 29875399
Levels of certain circulating cytokines and related immune system molecules are consistently altered in schizophrenia and related disorders. In addition to absolute analyte levels, we sought analytes in correlation networks...
8.
Zheutlin A, Jeffries C, Perkins D, Chung Y, Chekroud A, Addington J, et al.
Neuropsychopharmacology
. 2017 Feb;
42(11):2188-2195.
PMID: 28186095
In a recent report of the North American Prodrome Longitudinal Study (NAPLS), clinical high-risk individuals who converted to psychosis showed a steeper rate of cortical gray matter reduction compared with...
9.
Cannon T, Yu C, Addington J, Bearden C, Cadenhead K, Cornblatt B, et al.
Am J Psychiatry
. 2016 Jul;
173(10):980-988.
PMID: 27363508
Objective: Approximately 20%-35% of individuals 12-35 years old who meet criteria for a prodromal risk syndrome convert to psychosis within 2 years. However, this estimate ignores the fact that clinical...
10.
Jeffries C, Perkins D
Biol Psychiatry
. 2016 Jan;
80(5):e33-5.
PMID: 26774964
No abstract available.