Clarissa Willers
Overview
Explore the profile of Clarissa Willers including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
69
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Recent Articles
1.
Myburgh J, Liebenberg W, Willers C, Dube A, Gerber M
Pharmaceutics
. 2023 Oct;
15(10).
PMID: 37896173
The aim was to assess the suitability of three nano-based transdermal drug delivery systems containing ibuprofen: a nano-emulsion, a nano-emulgel, and a colloidal suspension with ibuprofen-loaded nanoparticles. Understanding the transdermal...
2.
Louw E, Liebenberg W, Willers C, Dube A, Aucamp M, Gerber M
Drug Deliv Transl Res
. 2022 Dec;
13(5):1372-1389.
PMID: 36525200
Transdermal delivery of active pharmaceutical ingredients (APIs) can be challenging, since the skin possesses a rate-limiting barrier, which may be overcome when APIs possess certain ideal physicochemical properties. The lack...
3.
van der Merwe L, Svitina H, Willers C, Wrzesinski K, Gouws C
Biotechnol Prog
. 2022 Apr;
38(4):e3253.
PMID: 35362670
Small cell lung cancer (SCLC) is aggressive and despite multiple clinical trials, its standard of care is unchanged for the past three decades. In vitro cancer models are crucial in...
4.
Gouws C, Smit T, Willers C, Svitina H, Calitz C, Wrzesinski K
Molecules
. 2021 Jan;
26(3).
PMID: 33503827
Colorectal cancer remains to be one of the leading causes of death worldwide, with millions of patients diagnosed each year. Although chemotherapeutic drugs are routinely used to treat cancer, these...
5.
Fouche M, Willers C, Hamman S, Malherbe C, Steenekamp J
Biology (Basel)
. 2020 Oct;
9(11).
PMID: 33113882
The traditional use of spp. for the purpose of wound healing has a long history and is widespread internationally. Recently, a hybrid aloe plant () has been cultivated by cross...
6.
Smit T, Calitz C, Willers C, Svitina H, Hamman J, Fey S, et al.
ACS Med Chem Lett
. 2020 May;
11(5):1014-1021.
PMID: 32435419
Colorectal cancer is one of the leading causes of cancer-related deaths. A main problem for its treatment is resistance to chemotherapy, requiring the development of new drugs. The success rate...
7.
Willers C, Svitina H, Rossouw M, Swanepoel R, Hamman J, Gouws C
J Cancer Res Clin Oncol
. 2019 Jul;
145(8):1949-1976.
PMID: 31292714
Purpose: Efflux transporters of the adenosine triphosphate-binding cassette (ABC)-superfamily play an important role in the development of multidrug resistance (multidrug resistant; MDR) in cancer. The overexpression of these transporters can...
8.
Haasbroek A, Willers C, Glyn M, du Plessis L, Hamman J
Pharmaceutics
. 2019 Jan;
11(1).
PMID: 30669246
The co-administration of absorption enhancing agents with macromolecular drugs (e.g., protein and peptide drugs) has been identified as a means to improve the oral bioavailability of these drugs. Absorption-enhancing agents...
9.
Absorptive and Secretory Transport of Selected Artemisinin Derivatives Across Caco-2 Cell Monolayers
Heyns J, Willers C, Haynes R, Wong H, Hamman J, Gouws C
Curr Drug Deliv
. 2018 May;
15(8):1183-1192.
PMID: 29779481
Background: Malaria continues to be a major health concern and affects more than 200 million people a year. Drugs currently used for treatment of malaria are increasingly rendered ineffectual by...
10.
Mmopele K, Combrinck S, Hamman J, Willers C, Chen W, Viljoen A
Planta Med
. 2018 Mar;
84(12-13):886-894.
PMID: 29554707
The African wild olive ( subsp. ) is traditionally used as a hypotensive agent. Herb-drug interactions may result from the concurrent use of herbal medicines and conventional prescription drugs. This...