Clare N Gallagher
Overview
Explore the profile of Clare N Gallagher including associated specialties, affiliations and a list of published articles.
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20
Citations
643
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Recent Articles
1.
Stovell M, Howe D, Thelin E, Jalloh I, Helmy A, Guilfoyle M, et al.
J Cereb Blood Flow Metab
. 2023 May;
43(10):1685-1701.
PMID: 37157814
How to optimise glucose metabolism in the traumatised human brain remains unclear, including whether injured brain can metabolise additional glucose when supplied. We studied the effect of microdialysis-delivered 1,2-C glucose...
2.
Yang R, Isaacs A, Cadieux M, Hirmer T, CreveCoeur T, Lapointe A, et al.
Childs Nerv Syst
. 2021 Mar;
37(6):1849-1858.
PMID: 33675391
Pediatric glioblastoma multiforme (GBM) involving the spine is an aggressive tumor with a poor quality of life for patients. Despite this, there is only a limited number of reports describing...
3.
Stovell M, Mada M, Carpenter T, Yan J, Guilfoyle M, Jalloh I, et al.
J Cereb Blood Flow Metab
. 2018 Sep;
40(1):67-84.
PMID: 30226401
Metabolic dysfunction is a key pathophysiological process in the acute phase of traumatic brain injury (TBI). Although changes in brain glucose metabolism and extracellular lactate/pyruvate ratio are well known, it...
4.
Stovell M, Mada M, Helmy A, Carpenter T, Thelin E, Yan J, et al.
Sci Rep
. 2018 Jul;
8(1):11140.
PMID: 30042490
A key pathophysiological process and therapeutic target in the critical early post-injury period of traumatic brain injury (TBI) is cell mitochondrial dysfunction; characterised by elevation of brain lactate/pyruvate (L/P) ratio...
5.
Kramer A, Couillard P, Zygun D, Aries M, Gallagher C
Neurocrit Care
. 2018 Jul;
30(1):51-61.
PMID: 29987688
Background: Guidelines recommend maintaining cerebral perfusion pressure (CPP) between 60 and 70 mmHg in patients with severe traumatic brain injury (TBI), but acknowledge that optimal CPP may vary depending on...
6.
Jalloh I, Helmy A, Howe D, Shannon R, Grice P, Mason A, et al.
J Neurotrauma
. 2018 Apr;
35(17):2025-2035.
PMID: 29690859
Metabolic abnormalities occur after traumatic brain injury (TBI). Glucose is conventionally regarded as the major energy substrate, although lactate can also be an energy source. We compared 3-C lactate metabolism...
7.
Jalloh I, Helmy A, Howe D, Shannon R, Grice P, Mason A, et al.
J Cereb Blood Flow Metab
. 2016 Nov;
37(7):2626-2638.
PMID: 27798266
Following traumatic brain injury, complex cerebral energy perturbations occur. Correlating with unfavourable outcome, high brain extracellular lactate/pyruvate ratio suggests hypoxic metabolism and/or mitochondrial dysfunction. We investigated whether focal administration of...
8.
Hutchinson P, Jalloh I, Helmy A, Carpenter K, Rostami E, Bellander B, et al.
Intensive Care Med
. 2015 Jul;
41(9):1517-28.
PMID: 26194024
Microdialysis enables the chemistry of the extracellular interstitial space to be monitored. Use of this technique in patients with acute brain injury has increased our understanding of the pathophysiology of...
9.
Jalloh I, Carpenter K, Grice P, Howe D, Mason A, Gallagher C, et al.
J Cereb Blood Flow Metab
. 2014 Oct;
35(1):111-20.
PMID: 25335801
Increased 'anaerobic' glucose metabolism is observed after traumatic brain injury (TBI) attributed to increased glycolysis. An alternative route is the pentose phosphate pathway (PPP), which generates putatively protective and reparative...
10.
Lama S, Auer R, Tyson R, Gallagher C, Tomanek B, Sutherland G
J Biol Chem
. 2014 May;
289(29):20200-8.
PMID: 24849602
Brain metabolism is thought to be maintained by neuronal-glial metabolic coupling. Glia take up glutamate from the synaptic cleft for conversion into glutamine, triggering glial glycolysis and lactate production. This...