Clara John
Overview
Explore the profile of Clara John including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
630
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0
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Recent Articles
1.
Sturznickel J, Behler-Janbeck F, Baranowsky A, Schmidt T, Schwinge D, John C, et al.
Sci Rep
. 2022 Oct;
12(1):16491.
PMID: 36192408
Primary sclerosing cholangitis (PSC) is an idiopathic cholestatic liver disease characterized by chronic inflammation and progressive fibrosis of intra- and extrahepatic bile ducts. Osteoporosis is a frequent comorbidity in PSC,...
2.
Evangelakos I, Kuhl A, Baguhl M, Schlein C, John C, Rohde J, et al.
Front Cell Dev Biol
. 2022 Apr;
10:836741.
PMID: 35478959
Brown adipose tissue (BAT) has emerged as an appealing therapeutic target for cardio metabolic diseases. BAT is a heat-producing organ and upon activation substantially lowers hyperlipidemia. In response to cold...
3.
Evangelakos I, Schwinge D, Worthmann A, John C, Roeder N, Pertzborn P, et al.
Cells
. 2021 Oct;
10(10).
PMID: 34685636
Ambient temperature is an important determinant of both the alternative bile acid synthesis pathway controlled by oxysterol 7-α hydroxylase (CYP7B1) and the progression of metabolic-associated fatty liver disease (MAFLD). Here,...
4.
Worthmann A, John C, Heeren J
Bio Protoc
. 2021 Aug;
8(13):e2916.
PMID: 34395745
The here described method can be used to estimate the uptake of orally provided cholesterol in mice. Briefly, mice are gavaged with radiolabeled cholesterol and 4 h later, organ distribution...
5.
Schaltenberg N, John C, Heine M, Haumann F, Rinninger F, Scheja L, et al.
Front Cardiovasc Med
. 2021 Mar;
8:628235.
PMID: 33748195
The physiologic activation of thermogenic brown and white adipose tissues (BAT/WAT) by cold exposure triggers heat production by adaptive thermogenesis, a process known to ameliorate hyperlipidemia and protect from atherosclerosis....
6.
Pauly M, Rohde J, John C, Evangelakos I, Koop A, Pertzborn P, et al.
Nutrients
. 2020 Oct;
12(10).
PMID: 33092056
Dietary fibers are fermented by gut bacteria into the major short chain fatty acids (SCFAs) acetate, propionate, and butyrate. Generally, fiber-rich diets are believed to improve metabolic health. However, recent...
7.
Liwinski T, Zenouzi R, John C, Ehlken H, Ruhlemann M, Bang C, et al.
Gut
. 2019 Jun;
69(4):665-672.
PMID: 31243055
Background: Patients with primary sclerosing cholangitis (PSC) display an altered colonic microbiome compared with healthy controls. However, little is known on the bile duct microbiome and its interplay with bile...
8.
Glaser F, John C, Engel B, Hoh B, Weidemann S, Dieckhoff J, et al.
J Hepatol
. 2019 Jun;
71(4):783-792.
PMID: 31207266
Background & Aims: T cells are central mediators of liver inflammation and represent potential treatment targets in cholestatic liver disease. Whereas emerging evidence shows that bile acids (BAs) affect T...
9.
Worthmann A, John C, Ruhlemann M, Baguhl M, Heinsen F, Schaltenberg N, et al.
Nat Med
. 2017 Jun;
23(7):839-849.
PMID: 28604703
Adaptive thermogenesis is an energy-demanding process that is mediated by cold-activated beige and brown adipocytes, and it entails increased uptake of carbohydrates, as well as lipoprotein-derived triglycerides and cholesterol, into...
10.
Bartelt A, John C, Schaltenberg N, Berbee J, Worthmann A, Cherradi M, et al.
Nat Commun
. 2017 Apr;
8:15010.
PMID: 28422089
Brown and beige adipocytes combust nutrients for thermogenesis and through their metabolic activity decrease pro-atherogenic remnant lipoproteins in hyperlipidemic mice. However, whether the activation of thermogenic adipocytes affects the metabolism...