Claire Denizot
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Explore the profile of Claire Denizot including associated specialties, affiliations and a list of published articles.
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25
Citations
228
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Recent Articles
1.
Fardel O, Moreau A, Jouan E, Denizot C, Le Vee M, Parmentier Y
Expert Opin Drug Metab Toxicol
. 2025 Jan;
1-18.
PMID: 39799554
Introduction: Drug-mediated inhibition of bile salt efflux transporters may cause liver injury. In vitro prediction of drug effects toward canalicular and/or sinusoidal efflux of bile salts from human hepatocytes is...
2.
Fardel O, Moreau A, Carteret J, Denizot C, Le Vee M, Parmentier Y
Eur J Drug Metab Pharmacokinet
. 2024 Jul;
49(5):527-539.
PMID: 38958896
The identification of substrates for solute carriers (SLCs) handling drugs is an important challenge, owing to the major implication of these plasma membrane transporters in pharmacokinetics and drug-drug interactions. In...
3.
Gomez-Zepeda D, Perriere N, Glacial F, Taghi M, Chhuon C, Scherrmann J, et al.
Toxicol Appl Pharmacol
. 2023 Mar;
465:116456.
PMID: 36918128
The blood-brain barrier (BBB) protects the brain from toxins but hinders the penetration of neurotherapeutic drugs. Therefore, the blood-to-brain permeability of chemotherapeutics must be carefully evaluated. Here, we aimed to...
4.
Le Vee M, Moreau A, Jouan E, Denizot C, Parmentier Y, Fardel O
Biopharm Drug Dispos
. 2022 Oct;
43(6):265-271.
PMID: 36195987
HepaRG cells are highly-differentiated human hepatoma cells, which are increasingly recognized as a convenient cellular model for in vitro evaluation of hepatic metabolism, transport, and/or toxicity of drugs. The present...
5.
Choublier N, Taghi M, Menet M, Le Gall M, Bruce J, Chafey P, et al.
Fluids Barriers CNS
. 2022 Jun;
19(1):41.
PMID: 35658915
Endothelial cells (ECs) are constantly submitted in vivo to hemodynamical forces derived from the blood circulation, including shear stress (SS). ECs are able to detect SS and consequently adapt their...
6.
Jouan E, Moreau A, Bruyere A, Alim K, Denizot C, Parmentier Y, et al.
Eur J Drug Metab Pharmacokinet
. 2021 Jul;
46(5):625-635.
PMID: 34275128
Background And Objectives: Equilibrative nucleoside transporter (ENT) 1 is a widely-expressed drug transporter, handling nucleoside analogues as well as endogenous nucleosides. ENT1 has been postulated to be inhibited by some...
7.
Alim K, Moreau A, Bruyere A, Jouan E, Denizot C, Nies A, et al.
Fundam Clin Pharmacol
. 2021 Feb;
35(5):919-929.
PMID: 33523504
Organic cation transporter (OCT) 3 (SLC22A3) is a widely expressed drug transporter, handling notably metformin and platinum derivatives, as well as endogenous compounds like monoamine neurotransmitters. OCT3 has been shown...
8.
Mayati A, Moreau A, Jouan E, Febvre-James M, Denizot C, Parmentier Y, et al.
Pharmaceutics
. 2018 Nov;
10(4).
PMID: 30469356
The HepaRG cell line is a highly differentiated human hepatoma cell line, displaying the expression of various drug transporters. However, functional expression of nucleoside transporters remains poorly characterized in HepaRG...
9.
Mayati A, Moreau A, Le Vee M, Bruyere A, Jouan E, Denizot C, et al.
Sci Rep
. 2018 Nov;
8(1):16115.
PMID: 30382126
HepaRG is an original human hepatoma cell line, acquiring highly differentiated hepatic features when exposed to dimethylsulfoxide (DMSO). To search alternatives to DMSO, which may exert some toxicity, we have...
10.
Fardel O, Moreau A, Le Vee M, Denizot C, Parmentier Y
Eur J Drug Metab Pharmacokinet
. 2018 Sep;
44(1):13-30.
PMID: 30167999
Evaluation of hepatobiliary transport of drugs is an important challenge, notably during the development of new molecular identities. In this context, sandwich-cultured human hepatocytes (SCHH) have been proposed as an...