Chuyong Lin
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Explore the profile of Chuyong Lin including associated specialties, affiliations and a list of published articles.
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60
Citations
1766
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Recent Articles
1.
Huang S, Shi D, Dai S, Jiang X, Wang R, Yang M, et al.
Clin Transl Med
. 2025 Feb;
15(2):e70203.
PMID: 39915011
Background: Resistance to paclitaxel-based chemotherapy is the major obstacle in triple-negative breast cancer (TNBC) treatment. However, overcoming paclitaxel resistance remains an unsolved problem. The present study aimed to determine whether...
2.
Chen S, Chen Z, Xu Q, Jiang X, Lin C, Ji J
Front Neurol
. 2024 Apr;
15:1359292.
PMID: 38628696
Background: To investigate the causal associations of serum urate (SUA) with stroke risk and prognosis using Mendelian randomization (MR) and the potential mediating role of stroke risk factors in the...
3.
Chen S, Chen Z, Jiang X, Lin C, Ji J
J Stroke Cerebrovasc Dis
. 2024 Feb;
33(4):107612.
PMID: 38309380
Objectives: Previous observational studies have suggested that gastroesophageal reflux disease (GERD) increases the risk of stroke, but the specific underlying mechanisms are unclear. We investigated the causal associations of GERD...
4.
He L, Chen J, Deng P, Huang S, Liu P, Wang C, et al.
Mol Cell
. 2023 Sep;
83(19):3502-3519.e11.
PMID: 37751742
Cyst(e)ine is a key precursor for the synthesis of glutathione (GSH), which protects cancer cells from oxidative stress. Cyst(e)ine is stored in lysosomes, but its role in redox regulation is...
5.
Yang M, Li Y, Kong L, Huang S, He L, Liu P, et al.
J Clin Invest
. 2023 Jul;
133(14).
PMID: 37463446
Human epidermal growth factor receptor 2-targeted (HER2-targeted) therapy is the mainstay of treatment for HER2+ breast cancer. However, the proteolytic cleavage of HER2, or HER2 shedding, induces the release of...
6.
Li Y, Chen B, Jiang X, Li Y, Wang X, Huang S, et al.
Cell Rep
. 2023 May;
42(6):112542.
PMID: 37210725
Alternative splicing (AS) is a critical mechanism for the aberrant biogenesis of long non-coding RNA (lncRNA). Although the role of Wnt signaling in AS has been implicated, it remains unclear...
7.
Wang X, Li Y, Xiao Y, Huang X, Wu X, Zhao Z, et al.
J Pathol
. 2023 Jan;
260(1):17-31.
PMID: 36715683
Macropinocytosis is an effective strategy to mitigate nutrient starvation. It can fuel cancer cell growth in nutrient-limited conditions. However, whether and how macropinocytosis contributes to the rapid proliferation of hepatocellular...
8.
Huang X, Shi D, Zou X, Wu X, Huang S, Kong L, et al.
Theranostics
. 2023 Jan;
13(1):339-354.
PMID: 36593950
Chemoresistance is a major challenge in the clinical management of patients with breast cancer. Mutant p53 proteins tend to form aggregates that promote tumorigenesis in cancers. We here aimed to...
9.
USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer
Shi D, Wu X, Jian Y, Wang J, Huang C, Mo S, et al.
Nat Commun
. 2022 Sep;
13(1):5644.
PMID: 36163134
Indoleamine 2,3 dioxygenase 1 (IDO1) is an attractive target for cancer immunotherapy. However, IDO1 inhibitors have shown disappointing therapeutic efficacy in clinical trials, mainly because of the activation of the...
10.
Xiao Y, Li Y, Shi D, Wang X, Dai S, Yang M, et al.
Cancer Res
. 2022 Sep;
82(22):4191-4205.
PMID: 36112698
Significance: This study reveals that RNA-binding protein MEX3C induces SOCS3 mRNA decay to promote JAK2/STAT3 activation and tumor metastasis in hepatocellular carcinoma, identifying MEX3C targeting as a potential approach for...