Chunwei Zheng
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Explore the profile of Chunwei Zheng including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
469
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Recent Articles
1.
Zheng C, Zhang G, Dean L, Sontheimer E, Xue W
Nat Biotechnol
. 2025 Feb;
PMID: 39962280
Reverse transcriptase (RT) has been shown to play a role in double-strand break repair in bacteria, yet the impact of the RT component of prime editors (PEs) on normal mammalian...
2.
Huang K, Cheng L, Jiang C, Zheng C, Cai H
PLoS One
. 2024 Nov;
19(11):e0313560.
PMID: 39576807
Osteoarthritis (OA) is a joint disease in which cartilage degradation is the hallmark pathological change. In this study, we investigated the anti-osteoarthritic effects of DHEA in rabbit chondrocytes. Polymerase chain...
3.
Zhang G, Zheng C, Ding Y, Mello C
Nat Commun
. 2024 Mar;
15(1):2727.
PMID: 38548791
Piwi-interacting RNAs (piRNAs) are genomically encoded small RNAs that engage Piwi Argonaute proteins to direct mRNA surveillance and transposon silencing. Despite advances in understanding piRNA pathways and functions, how the...
4.
Liu B, Dong X, Zheng C, Keener D, Chen Z, Cheng H, et al.
Nat Biotechnol
. 2023 Sep;
42(7):1039-1045.
PMID: 37709915
Reverse transcriptases, used in prime editing systems, exhibit lower fidelity, processivity and dNTP affinity than many DNA-dependent DNA polymerases. We report that a DNA-dependent DNA polymerase (phi29), untethered from Cas9,...
5.
Zhang G, Zheng C, Ding Y, Mello C
bioRxiv
. 2023 Aug;
PMID: 37609319
Piwi-interacting RNAs (piRNAs) are genomically encoded small RNAs that engage Piwi Argonaute proteins to direct mRNA surveillance and transposon silencing. Despite advances in understanding piRNA pathways and functions, how the...
6.
Zheng C, Liu B, Dong X, Gaston N, Sontheimer E, Xue W
Nat Commun
. 2023 Jun;
14(1):3369.
PMID: 37291100
Targeted insertion of large DNA fragments holds promise for genome engineering and gene therapy. Prime editing (PE) effectively inserts short (<50 bp) sequences. Employing paired prime editing guide RNAs (pegRNAs)...
7.
Chen J, Gao C, Luo M, Zheng C, Lin X, Ning Y, et al.
EMBO Rep
. 2022 Jun;
23(8):e54298.
PMID: 35712867
MicroRNAs (miRNAs) are believed to play important roles in mammalian spermatogenesis but the in vivo functions of single miRNAs in this highly complex developmental process remain unclear. Here, we report...
8.
Liu B, Dong X, Cheng H, Zheng C, Chen Z, Rodriguez T, et al.
Nat Biotechnol
. 2022 Apr;
40(9):1388-1393.
PMID: 35379962
Delivery and optimization of prime editors (PEs) have been hampered by their large size and complexity. Although split versions of genome-editing tools can reduce construct size, they require special engineering...
9.
Zheng C, Liang S, Liu B, Liu P, Kwan S, Wolfe S, et al.
Mol Ther
. 2022 Jan;
30(3):1343-1351.
PMID: 34998953
Prime editor (PE) has tremendous promise for gene therapy. However, it remains a challenge to deliver PE (>6.3 kb) in vivo. Although PE can be split into two fragments and...
10.
Chen J, Gao C, Lin X, Ning Y, He W, Zheng C, et al.
Development
. 2021 Dec;
148(24).
PMID: 34913465
Spermatogonial differentiation and meiotic initiation during spermatogenesis are tightly regulated by a number of genes, including those encoding enzymes for miRNA biogenesis. However, whether and how single miRNAs regulate these...