Chunliang Xu
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Explore the profile of Chunliang Xu including associated specialties, affiliations and a list of published articles.
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30
Citations
1968
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Recent Articles
1.
Takeishi S, Marchand T, Koba W, Borger D, Xu C, Guha C, et al.
bioRxiv
. 2023 Nov;
PMID: 37961493
Haematopoietic stem cells (HSCs) reside in specialized microenvironments, also referred to as niches, and it has been widely believed that HSC numbers are determined by the niche size alone ....
2.
Poller W, Downey J, Mooslechner A, Khan N, Li L, Chan C, et al.
Nature
. 2022 May;
607(7919):578-584.
PMID: 35636458
The nervous and immune systems are intricately linked. Although psychological stress is known to modulate immune function, mechanistic pathways linking stress networks in the brain to peripheral leukocytes remain poorly...
3.
Zhang T, Wang Y, Li Q, Lin L, Xu C, Xue Y, et al.
Oncogene
. 2022 Feb;
41(13):1866-1881.
PMID: 35145233
Cancer treatments have been revolutionized by the emergence of immune checkpoint blockade therapies. However, only a minority of patients with various tumor types have benefited from such treatments. New strategies...
4.
Zhang D, Gao X, Li H, Borger D, Wei Q, Yang E, et al.
Cell Stem Cell
. 2022 Jan;
29(2):232-247.e7.
PMID: 35065706
Host microbiota crosstalk is essential for the production and functional modulation of blood-cell lineages. Whether, and if so how, the microbiota influences hematopoietic stem cells (HSCs) is unclear. Here, we...
5.
Lu Y, Pu Z, Chen J, Deng J, Deng Y, Zhu S, et al.
J Vis Exp
. 2021 Nov;
(176).
PMID: 34747411
Type 1 diabetes mellitus (T1DM) is caused by autoimmune destruction of pancreatic β cells, which results in little or no insulin production. Islet transplantation plays an important role in the...
6.
Wei Q, Pinho S, Dong S, Pierce H, Li H, Nakahara F, et al.
Nat Commun
. 2021 May;
12(1):2522.
PMID: 33947846
Haematopoietic stem cells (HSCs) tightly regulate their quiescence, proliferation, and differentiation to generate blood cells during the entire lifetime. The mechanisms by which these critical activities are balanced are still...
7.
Gao X, Zhang D, Xu C, Li H, Caron K, Frenette P
Nature
. 2020 Dec;
589(7843):591-596.
PMID: 33361809
Haematopoietic stem cells (HSCs) reside in specialized microenvironments in the bone marrow-often referred to as 'niches'-that represent complex regulatory milieux influenced by multiple cellular constituents, including nerves. Although sympathetic nerves...
8.
Xu C, Gulinello M, Frenette P
J Exp Med
. 2020 Oct;
218(1).
PMID: 33045060
Sickle cell disease (SCD) is a common hereditary hematologic disorder. SCD patients suffer from acute vaso-occlusive episodes (VOEs), chronic organ damage, and premature death, with few therapeutic options. Although severe...
9.
Manwani D, Xu C, Lee S, Amatuni G, Cohen H, Carullo V, et al.
Complement Ther Med
. 2020 Sep;
52:102481.
PMID: 32951731
Sickle Cell Disease (SCD) is a chronic hemolytic disorder associated with frequent pain episodes, end organ damage and a shortened lifespan. Currently there exist no disease specific targeted therapies for...
10.
Xu C, Lee S, Zhang D, Frenette P
Immunity
. 2020 Aug;
53(2):417-428.e4.
PMID: 32735844
Psychological stress has adverse effects on various human diseases, including those of the cardiovascular system. However, the mechanisms by which stress influences disease activity remain unclear. Here, using vaso-occlusive episodes...