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Chun-Hao Chan

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Articles 9
Citations 52
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Recent Articles
1.
Chan C, Deng Y, Peng B, Chiang P, Wu L, Lee Y, et al.
Integr Cancer Ther . 2023 Dec; 22:15347354231213613. PMID: 38059303
Background: -derived fucoidan, a multifunctional bioactive polysaccharide sourced from marine organisms, exhibits a wide range of therapeutic properties, including its anti-tumor effects. While previous research has reported on its anti-cancer...
2.
Peng B, Singh A, Tsai C, Chan C, Deng Y, Wu C, et al.
J Biomed Sci . 2023 Sep; 30(1):77. PMID: 37691117
Background: Bioactive materials have now raised considerable attention for the treatment of osteoarthritis (OA), such as knee OA, rheumatoid OA, and temporomandibular joint (TMJ) OA. TMJ-OA is a common disease...
3.
Singh A, Peng B, Chien S, Chan C, Deng Y, Pai H, et al.
Biomater Sci . 2023 May; 11(13):4522-4536. PMID: 37158091
Aging involves tissue and cell potential dysfunction characterized by stem cell senescence and extracellular matrix microenvironment (ECM) alteration. Chondroitin sulfate (CS), found in the ECM of normal cells and tissues,...
4.
Peng B, Singh A, Chan C, Deng Y, Li P, Su C, et al.
BMC Cancer . 2023 Jan; 23(1):1. PMID: 36597025
Background: Despite the advancement in chemotherapeutic drugs for colon cancer treatment, it is still a life-threatening disease worldwide due to drug resistance. Therefore, an urgently needed to develop novel drugs...
5.
Lo W, Chang C, Chan C, Singh A, Deng Y, Lin C, et al.
Life (Basel) . 2021 Oct; 11(10). PMID: 34685425
Complications of diabetes mellitus (DM) range from acute to chronic conditions, leading to multiorgan disorders such as nephropathy, retinopathy, and neuropathy. However, little is known about the influence of DM...
6.
Lo W, Chiou C, Tsai F, Chan C, Mao S, Deng Y, et al.
Cell Transplant . 2021 Sep; 30:9636897211045319. PMID: 34586895
Apart from aging process, adult intervertebral disc (IVD) undergoes various degenerative processes. However, the nicotine has not been well identified as a contributing etiology. According to a few studies, nicotine...
7.
Chan C, Wu C, Dubey N, Wei H, Lu J, Mao S, et al.
Aging (Albany NY) . 2020 Aug; 12(18):17930-17947. PMID: 32759461
Recent reports have indicated the role of highly expressed methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) enzyme in cancers, showing poor survival; however, detailed mechanistic insight of metabolic functions of MTHFD2 have not...
8.
Wu C, Chan C, Dubey N, Wei H, Lu J, Chang C, et al.
Int J Mol Sci . 2020 May; 21(9). PMID: 32370197
Cancer pathogenesis results from genetic alteration-induced high or low transcriptional programs, which become highly dependent on regulators of gene expression. However, their role in progressive regulation of non-small-cell lung cancer...
9.
Dubey N, Peng B, Lin C, Wang P, Wang J, Chan C, et al.
Int J Mol Sci . 2018 Jun; 19(6). PMID: 29857489
NSC 95397, a quinone-based small molecule compound, has been identified as an inhibitor for dual-specificity phosphatases, including mitogen-activated protein kinase phosphatase-1 (MKP-1). MKP-1 is known to inactivate mitogen-activated protein kinases...