Chuan-Yun Li
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Explore the profile of Chuan-Yun Li including associated specialties, affiliations and a list of published articles.
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60
Citations
4011
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Recent Articles
11.
An N, Zhang J, Mo F, Luan X, Tian L, Shen Q, et al.
Nat Ecol Evol
. 2023 Jan;
7(2):264-278.
PMID: 36593289
Human de novo genes can originate from neutral long non-coding RNA (lncRNA) loci and are evolutionarily significant in general, yet how and why this all-or-nothing transition to functionality happens remains...
12.
Zhou W, Li W, Shen H, Wang R, Chen W, Zhang Y, et al.
Genomics Proteomics Bioinformatics
. 2022 Aug;
21(1):216-227.
PMID: 35961607
Congenital heart disease (CHD) is one of themost common causes of major birth defects, with a prevalence of 1%. Although an increasing number of studies have reported the etiology of...
13.
Ding S, Liu J, Han X, Ding W, Liu Z, Zhu Y, et al.
J Mol Cell Cardiol
. 2022 Jun;
170:75-86.
PMID: 35714558
Long noncoding RNAs (lncRNAs) are critical regulators of inflammation with great potential as new therapeutic targets. However, the role of lncRNAs in early atherosclerosis remains poorly characterized. This study aimed...
14.
Wang F, He J, Liu S, Gao A, Yang L, Sun G, et al.
Blood
. 2021 Aug;
138(20):1939-1952.
PMID: 34388251
Adenosine-to-inosine RNA editing and the catalyzing enzyme adenosine deaminase are both essential for hematopoietic development and differentiation. However, the RNA editome during hematopoiesis and the underlying mechanisms are poorly defined....
15.
Li Y, Shen Q, Peng Q, Ding W, Zhang J, Zhong X, et al.
Brief Bioinform
. 2021 May;
22(6).
PMID: 33973996
Rhesus macaque is a unique nonhuman primate model for human evolutionary and translational study, but the error-prone gene models critically limit its applications. Here, we de novo defined full-length macaque...
16.
Feng Y, Xu H, Liu J, Xie N, Gao L, He Y, et al.
Mol Biol Evol
. 2021 Mar;
38(7):2930-2945.
PMID: 33744959
Cis-regulatory elements play important roles in tissue-specific gene expression and in the evolution of various phenotypes, and mutations in promoters and enhancers may be responsible for adaptations of species to...
17.
Li Y, Ding W, Li C, Liu Y
Nat Commun
. 2020 Nov;
11(1):5959.
PMID: 33235199
The ability of organisms to sense nutrient availability and tailor their metabolic states to withstand nutrient deficiency is critical for survival. To identify previously unknown regulators that couple nutrient deficiency...
18.
Shao L, Peng Q, Dong M, Gao K, Li Y, Li Y, et al.
Nat Commun
. 2020 Sep;
11(1):4639.
PMID: 32934238
The ability to detect, respond and adapt to mitochondrial stress ensures the development and survival of organisms. Caenorhabditis elegans responds to mitochondrial stress by activating the mitochondrial unfolded protein response...
19.
Wu D, Jian C, Peng Q, Hou T, Wu K, Shang B, et al.
Cell Death Dis
. 2020 Mar;
11(3):181.
PMID: 32165613
Fatty acids are the most major substrate source for adult cardiac energy generation. Prohibitin 2 (PHB2), a highly conserved protein located in mitochondrial inner membrane, plays key roles in cellular...
20.
Zhang M, Gao H, Liu D, Zhong X, Shi X, Yu P, et al.
Nat Cell Biol
. 2019 Sep;
21(9):1152-1163.
PMID: 31481791
Ca/calmodulin-dependent kinase II (CaMKII) is a multifunctional serine/threonine kinase family, and its δ isoform is predominant in the heart. Excessive CaMKII activation plays a pivotal role in the pathogenesis of...