Christos Chinopoulos
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Explore the profile of Christos Chinopoulos including associated specialties, affiliations and a list of published articles.
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87
Citations
2543
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Recent Articles
1.
Lee D, Ta L, Mukherjee P, Duraj T, Domin M, Greenwood B, et al.
ASN Neuro
. 2024 Dec;
16(1):2422268.
PMID: 39621724
Energy is necessary for tumor cell viability and growth. Aerobic glucose-driven lactic acid fermentation is a common metabolic phenotype seen in most cancers including malignant gliomas. This metabolic phenotype is...
2.
Dora F, Hajdu T, Renner E, Paal K, Alpar A, Palkovits M, et al.
Transl Psychiatry
. 2024 Nov;
14(1):479.
PMID: 39604371
A moderating hub between resting state networks (RSNs) and the medial temporal lobe (MTL) is the parahippocampal cortex (PHC). Abnormal activity has been reported in depressed patients and suicide attempters...
3.
Dobolyi A, Cservenak M, Bago A, Chen C, Stepanova A, Paal K, et al.
Commun Biol
. 2024 Aug;
7(1):1045.
PMID: 39181993
The astrocyte-to-neuron lactate shuttle model entails that, upon glutamatergic neurotransmission, glycolytically derived pyruvate in astrocytes is mainly converted to lactate instead of being entirely catabolized in mitochondria. The mechanism of...
4.
Chinopoulos C
Biochem Soc Trans
. 2024 Mar;
52(2):529-538.
PMID: 38526218
Certain cancer cells within solid tumors experience hypoxia, rendering them incapable of oxidative phosphorylation (OXPHOS). Despite this oxygen deficiency, these cells exhibit biochemical pathway activity that relies on NAD+. This...
5.
Ravasz D, Bui D, Nazarian S, Pallag G, Karnok N, Roberts J, et al.
Sci Rep
. 2024 Jan;
14(1):1729.
PMID: 38242919
Anoxia halts oxidative phosphorylation (OXPHOS) causing an accumulation of reduced compounds in the mitochondrial matrix which impedes dehydrogenases. By simultaneously measuring oxygen concentration, NADH autofluorescence, mitochondrial membrane potential and ubiquinone...
6.
Doczi J, Karnok N, Bui D, Azarov V, Pallag G, Nazarian S, et al.
Sci Rep
. 2023 Jul;
13(1):10822.
PMID: 37402778
Alterations in metabolism are a hallmark of cancer. It is unclear if oxidative phosphorylation (OXPHOS) is necessary for tumour cell survival. In this study, we investigated the effects of severe...
7.
Seyfried T, Arismendi-Morillo G, Zuccoli G, Lee D, Duraj T, Elsakka A, et al.
Front Oncol
. 2022 Sep;
12:968351.
PMID: 36059707
Glioblastoma (GBM), similar to most cancers, is dependent on fermentation metabolism for the synthesis of biomass and energy (ATP) regardless of the cellular or genetic heterogeneity seen within the tumor....
8.
Horvath G, Svab G, Komlodi T, Ravasz D, Kacso G, Doczi J, et al.
Antioxidants (Basel)
. 2022 Aug;
11(8).
PMID: 36009207
α-ketoglutarate dehydrogenase complex (KGDHc), or 2-oxoglutarate dehydrogenase complex (OGDHc) is a rate-limiting enzyme in the tricarboxylic acid cycle, that has been identified in neurodegenerative diseases such as in Alzheimer's disease....
9.
Pallag G, Nazarian S, Ravasz D, Bui D, Komlodi T, Doerrier C, et al.
Int J Mol Sci
. 2022 May;
23(9).
PMID: 35563503
The oxidation of proline to pyrroline-5-carboxylate (P5C) leads to the transfer of electrons to ubiquinone in mitochondria that express proline dehydrogenase (ProDH). This electron transfer supports Complexes CIII and CIV,...
10.
Seyfried T, Chinopoulos C
Metabolites
. 2021 Sep;
11(9).
PMID: 34564387
A theory that can best explain the facts of a phenomenon is more likely to advance knowledge than a theory that is less able to explain the facts. Cancer is...