Christopher T Pappas
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Explore the profile of Christopher T Pappas including associated specialties, affiliations and a list of published articles.
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25
Citations
860
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Recent Articles
1.
Iwanski J, Pappas C, Mayfield R, Farman G, Ahrens-Nicklas R, Churko J, et al.
NPJ Regen Med
. 2024 Sep;
9(1):21.
PMID: 39285234
Neonatal dilated cardiomyopathy (DCM) is a poorly understood muscular disease of the heart. Several homozygous biallelic variants in LMOD2, the gene encoding the actin-binding protein Leiomodin 2, have been identified...
2.
Pappas C, Mayfield R, Dickerson A, Mi-Mi L, Gregorio C
PLoS Genet
. 2024 May;
20(5):e1011279.
PMID: 38748723
The leiomodin (Lmod) family of actin-binding proteins play a critical role in muscle function, highlighted by the fact that mutations in all three family members (LMOD1-3) result in human myopathies....
3.
Larrinaga T, Farman G, Mayfield R, Yuen M, Ahrens-Nicklas R, Cooper S, et al.
Sci Adv
. 2024 Mar;
10(11):eadk1890.
PMID: 38478604
Muscle contraction is a regulated process driven by the sliding of actin-thin filaments over myosin-thick filaments. Lmod2 is an actin filament length regulator and essential for life since human mutations...
4.
Yuen M, Worgan L, Iwanski J, Pappas C, Joshi H, Churko J, et al.
Eur J Hum Genet
. 2022 Jan;
30(4):450-457.
PMID: 35082396
Dilated cardiomyopathy (DCM) is characterized by cardiac enlargement and impaired ventricular contractility leading to heart failure. A single report identified variants in leiomodin-2 (LMOD2) as a cause of neonatally-lethal DCM....
5.
Mi-Mi L, Farman G, Mayfield R, Strom J, Chu M, Pappas C, et al.
PLoS One
. 2020 Jan;
15(1):e0226138.
PMID: 31899774
A novel cardiac-specific transgenic mouse model was generated to identify the physiological consequences of elongated thin filaments during post-natal development in the heart. Remarkably, increasing the expression levels in vivo...
6.
Ahrens-Nicklas R, Pappas C, Farman G, Mayfield R, Larrinaga T, Medne L, et al.
Sci Adv
. 2019 Sep;
5(9):eaax2066.
PMID: 31517052
Neonatal heart failure is a rare, poorly-understood presentation of familial dilated cardiomyopathy (DCM). Exome sequencing in a neonate with severe DCM revealed a homozygous nonsense variant in leiomodin 2 (,...
7.
Ly T, Pappas C, Johnson D, Schlecht W, Colpan M, Galkin V, et al.
Mol Biol Cell
. 2018 Nov;
30(2):268-281.
PMID: 30462572
Missense mutations K15N and R21H in striated muscle tropomyosin are linked to dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), respectively. Tropomyosin, together with the troponin complex, regulates muscle contraction and,...
8.
Pappas C, Farman G, Mayfield R, Konhilas J, Gregorio C
J Mol Cell Cardiol
. 2018 Aug;
122:88-97.
PMID: 30102883
Leiomodin-2 (Lmod2) is a striated muscle-specific actin binding protein that is implicated in assembly of thin filaments. The necessity of Lmod2 in the adult mouse and role it plays in...
9.
Wu T, Mu Y, Bogomolovas J, Fang X, Veevers J, Nowak R, et al.
Proc Natl Acad Sci U S A
. 2017 Oct;
114(45):11956-11961.
PMID: 29078393
Small heat shock protein HSPB7 is highly expressed in the heart. Several mutations within HSPB7 are associated with dilated cardiomyopathy and heart failure in human patients. However, the precise role...
10.
Ly T, Moroz N, Pappas C, Novak S, Tolkatchev D, Wooldridge D, et al.
Mol Biol Cell
. 2016 Jun;
27(16):2565-75.
PMID: 27307584
Leiomodin is a potent actin nucleator related to tropomodulin, a capping protein localized at the pointed end of the thin filaments. Mutations in leiomodin-3 are associated with lethal nemaline myopathy...