Christopher Ruis
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Explore the profile of Christopher Ruis including associated specialties, affiliations and a list of published articles.
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32
Citations
3267
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Recent Articles
1.
Otieno J, Ruis C, Onoja A, Kuppalli K, Hoxha A, Nitsche A, et al.
Nat Med
. 2024 Oct;
31(1):342-350.
PMID: 39442559
Monkeypox virus (MPXV) is endemic in western and Central Africa, and in May 2022, a clade IIb lineage (B.1) caused a global outbreak outside Africa, resulting in its detection in...
2.
Goya S, Ruis C, Neher R, Meijer A, Aziz A, Hinrichs A, et al.
Emerg Infect Dis
. 2024 Jul;
30(8):1631-1641.
PMID: 39043393
A globally implemented unified phylogenetic classification for human respiratory syncytial virus (HRSV) below the subgroup level remains elusive. We formulated global consensus of HRSV classification on the basis of the...
3.
Weimann A, Dinan A, Ruis C, Bernut A, Pont S, Brown K, et al.
Science
. 2024 Jul;
385(6704):eadi0908.
PMID: 38963857
The major human bacterial pathogen causes multidrug-resistant infections in people with underlying immunodeficiencies or structural lung diseases such as cystic fibrosis (CF). We show that a few environmental isolates, driven...
4.
Hunt M, Hinrichs A, Anderson D, Karim L, Dearlove B, Knaggs J, et al.
bioRxiv
. 2024 May;
PMID: 38746185
The SARS-CoV-2 genome occupies a unique place in infection biology - it is the most highly sequenced genome on earth (making up over 20% of public sequencing datasets) with fine...
5.
McBroome J, de Bernardi Schneider A, Roemer C, Wolfinger M, Hinrichs A, OToole A, et al.
Nat Microbiol
. 2024 Feb;
9(2):550-560.
PMID: 38316930
Pathogen lineage nomenclature systems are a key component of effective communication and collaboration for researchers and public health workers. Since February 2021, the Pango dynamic lineage nomenclature for SARS-CoV-2 has...
6.
Ruis C, Weimann A, Tonkin-Hill G, Pandurangan A, Matuszewska M, Murray G, et al.
Nat Commun
. 2023 Nov;
14(1):7091.
PMID: 37925514
As observed in cancers, individual mutagens and defects in DNA repair create distinctive mutational signatures that combine to form context-specific spectra within cells. We reasoned that similar processes must occur...
7.
Roemer C, Sheward D, Hisner R, Gueli F, Sakaguchi H, Frohberg N, et al.
Nat Microbiol
. 2023 Oct;
8(11):1952-1959.
PMID: 37845314
Since SARS-CoV-2 BA.5 (Omicron) emerged and spread in 2022, Omicron lineages have markedly diversified. Here we review the evolutionary trajectories and processes that underpin the emergence of these lineages, and...
8.
Sanderson T, Hisner R, Donovan-Banfield I, Hartman H, Lochen A, Peacock T, et al.
Nature
. 2023 Sep;
623(7987):594-600.
PMID: 37748513
Molnupiravir, an antiviral medication widely used against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), acts by inducing mutations in the virus genome during replication. Most random mutations are likely to...
9.
On Y, Figueroa W, Fan C, Ho P, Benyei E, Weimann A, et al.
ISME J
. 2023 Sep;
17(11):1931-1939.
PMID: 37666975
Once acquired, hypermutation is unrelenting, and in the long-term, leads to impaired fitness due to its cumulative impact on the genome. This raises the question of why hypermutators arise so...
10.
Ruis C, Peacock T, Polo L, Masone D, Alvarez M, Hinrichs A, et al.
Microb Genom
. 2023 May;
9(5).
PMID: 37185044
Exposure to different mutagens leaves distinct mutational patterns that can allow inference of pathogen replication niches. We therefore investigated whether SARS-CoV-2 mutational spectra might show lineage-specific differences, dependent on the...