Christopher O Miles
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Explore the profile of Christopher O Miles including associated specialties, affiliations and a list of published articles.
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117
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1228
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Recent Articles
1.
Cottrill K, Miles C, Krajewski L, Cunningham B, Bragg W, Boise N, et al.
Harmful Algae
. 2024 Nov;
139:102739.
PMID: 39567074
Background: Microcystins are an emergent public health problem. These toxins are secondary metabolites of harmful cyanobacterial blooms, with blooms becoming more prevalent with eutrophication of water. Exposure to microcystins can...
2.
Mudge E, Wilkins A, Murray J, Rise F, Miles C
Toxicon
. 2024 Nov;
251:108154.
PMID: 39490818
Gambierones are sulfated polyethers produced by benthic dinoflagellates in the genera Gambierdiscus, Coolia and Fukuyoa. While relative toxicity data for gambierones suggests they are low compared with ciguatoxin analogues, gambierones...
3.
Miles C, Burton I, Lewis N, Robertson A, Giddings S, McCarron P, et al.
Tetrahedron
. 2024 Jul;
162.
PMID: 39006909
Ciguatera poisoning occurs throughout subtropical and tropical regions globally. The Virgin Islands in the Caribbean Sea is a known hyperendemic region for ciguatera and has been associated with Caribbean ciguatoxin...
4.
Wang X, Fon M, Andersen A, Solhaug A, Ingebrigtsen R, Samdal I, et al.
Harmful Algae
. 2024 Jul;
137:102681.
PMID: 39003025
In May-June 2019, the microalga Chrysochromulina leadbeateri caused a massive fish-killing event in several fjords in Northern Norway, resulting in the largest direct impact ever on aquaculture in northern Europe...
5.
Miles C, McCarron P, Thomas K, Al-Sinawi B, Liu T, Neilan B
ACS Omega
. 2024 Jul;
9(25):27618-27631.
PMID: 38947807
Microcystins are hepatotoxic cyclic heptapeptides produced by some cyanobacterial species and usually contain the unusual β-amino acid 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoic acid (Adda) at position-5. The full microcystin gene cluster from PCC 7806...
6.
Van Hassel W, Abdallah M, Gracia Guzman Velasquez M, Miles C, Samdal I, Masquelier J, et al.
Environ Pollut
. 2024 Mar;
347:123715.
PMID: 38462191
Microcystin-LR (MC-LR) is a hepatotoxic metabolite that naturally occurs during some cyanobacterial blooms in eutrophic waterbodies, and irrigation of edible plants with MC-LR-contaminated water causes bioaccumulation of the toxin. However,...
7.
Mudge E, Robertson A, Uhlig S, McCarron P, Miles C
Toxicon
. 2023 Dec;
237:107536.
PMID: 38043714
Ciguatera poisoning (CP) is endemic to several subtropical and tropical regions and is caused by the consumption of fish contaminated with ciguatoxins (CTXs). The recent discovery of Caribbean CTXs (C-CTXs)...
8.
Miles C, Strand D, Rusch J, Ballot A, Haande S, Lovberg K, et al.
Environ Res
. 2023 Nov;
242:117623.
PMID: 37956753
Lake Steinsfjorden, an important noble crayfish (Astacus astacus) habitat, is often affected by blooms of Planktothrix spp. that produce microcystins (MCs). A poor correlation between MCs by ELISA in the...
9.
Wright E, Meija J, McCarron P, Miles C
Anal Bioanal Chem
. 2023 Aug;
415(24):5973-5983.
PMID: 37530793
Azaspiracids (AZAs) are a group of polyether marine algal toxins known to accumulate in shellfish, posing a risk to human health and the seafood industry. Analysis of AZAs is typically...
10.
Beach D, Zamlynny L, MacArthur M, Miles C
Anal Bioanal Chem
. 2023 Jul;
415(22):5281-5296.
PMID: 37507466
Anatoxins (ATXs) are a potent class of cyanobacterial neurotoxins for which only a handful of structural analogues have been well characterized. Here, we report the development of an LC-HRMS/MS method...