Christopher N Parkhurst
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Explore the profile of Christopher N Parkhurst including associated specialties, affiliations and a list of published articles.
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30
Citations
4131
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Recent Articles
1.
Won T, Arifuzzaman M, Parkhurst C, Miranda I, Zhang B, Hu E, et al.
Nature
. 2025 Jan;
638(8049):216-224.
PMID: 39779854
Metabolites derived from the intestinal microbiota, including bile acids (BA), extensively modulate vertebrate physiology, including development, metabolism, immune responses and cognitive function. However, to what extent host responses balance the...
2.
Kusakabe T, Lin W, Cheong J, Singh G, Ravishankar A, Yeung S, et al.
Nat Immunol
. 2023 Oct;
24(11):1879-1889.
PMID: 37872315
Gastrointestinal fungal dysbiosis is a hallmark of several diseases marked by systemic immune activation. Whether persistent pathobiont colonization during immune alterations and impaired gut barrier function has a durable impact...
3.
Wang Z, Lipshutz A, Liu Z, Trzeciak A, Miranda I, Martinez de la Torre C, et al.
bioRxiv
. 2023 Aug;
PMID: 37645894
Despite the success of fructose as a low-cost food additive, recent epidemiological evidence suggests that high fructose consumption by pregnant mothers or during adolescence is associated with disrupted neurodevelopment ....
4.
Cheong J, Ravishankar A, Sharma S, Parkhurst C, Grassmann S, Wingert C, et al.
Cell
. 2023 Aug;
186(18):3882-3902.e24.
PMID: 37597510
Inflammation can trigger lasting phenotypes in immune and non-immune cells. Whether and how human infections and associated inflammation can form innate immune memory in hematopoietic stem and progenitor cells (HSPC)...
5.
Trzeciak A, Rojas W, Liu Z, Krebs A, Wang Z, Saavedra P, et al.
bioRxiv
. 2023 Jun;
PMID: 37383948
Highlights: Myeloid-specific WNK1 loss causes failed macrophage development and premature deathM-CSF-stimulated myeloid progenitors and precursors become neutrophils instead of macrophagesM-CSF induces macropinocytosis by myeloid progenitors, which depends on WNK1Macropinocytosis enforces...
6.
Tsou A, Yano H, Parkhurst C, Mahlakoiv T, Chu C, Zhang W, et al.
Nature
. 2022 Nov;
611(7937):787-793.
PMID: 36323781
Emerging studies indicate that cooperation between neurons and immune cells regulates antimicrobial immunity, inflammation and tissue homeostasis. For example, a neuronal rheostat provides excitatory or inhibitory signals that control the...
7.
Arifuzzaman M, Won T, Li T, Yano H, Digumarthi S, Heras A, et al.
Nature
. 2022 Nov;
611(7936):578-584.
PMID: 36323778
Dietary fibres can exert beneficial anti-inflammatory effects through microbially fermented short-chain fatty acid metabolites<sup>1,2</sup>, although the immunoregulatory roles of most fibre diets and their microbiota-derived metabolites remain poorly defined. Here,...
8.
Zhang W, Lyu M, Bessman N, Xie Z, Arifuzzaman M, Yano H, et al.
Cell
. 2022 Oct;
185(22):4170-4189.e20.
PMID: 36240781
Nociceptive pain is a hallmark of many chronic inflammatory conditions including inflammatory bowel diseases (IBDs); however, whether pain-sensing neurons influence intestinal inflammation remains poorly defined. Employing chemogenetic silencing, adenoviral-mediated colon-specific...
9.
Trzeciak A, Mongre R, Kim M, Lim K, Madero R, Parkhurst C, et al.
Front Immunol
. 2022 Aug;
13:965305.
PMID: 35983035
Sepsis is a life-threatening systemic inflammatory condition causing approximately 11 million annual deaths worldwide. Although key hyperinflammation-based organ dysfunctions that drive disease pathology have been recognized, our understanding of the...
10.
Price D, Benedetti E, Hoffman K, Gomez-Escobar L, Alvarez-Mulett S, Capili A, et al.
Am J Pathol
. 2022 Apr;
192(7):1001-1015.
PMID: 35469796
Vascular injury is a well-established, disease-modifying factor in acute respiratory distress syndrome (ARDS) pathogenesis. Recently, coronavirus disease 2019 (COVID-19)-induced injury to the vascular compartment has been linked to complement activation,...