Christopher M Dustin
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Explore the profile of Christopher M Dustin including associated specialties, affiliations and a list of published articles.
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18
Citations
253
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Recent Articles
1.
Dustin C, Shiva S, Vazquez A, Saeed A, Pascoal T, Cifuentes-Pagano E, et al.
Redox Biol
. 2024 Dec;
78:103433.
PMID: 39616884
Alzheimer's Disease (AD), and related dementias, represent a growing concern for the worldwide population given the increased numbers of people of advanced age. Marked by significant degradation of neurological tissues...
2.
Zang J, Peters F, Cambet Y, Cifuentes-Pagano E, Hissabu M, Dustin C, et al.
J Med Chem
. 2023 Oct;
66(21):14963-15005.
PMID: 37857466
Nicotinamide adenine dinucleotide phosphate oxidase isoform 2 (NOX2) is an enzymatic complex whose function is the regulated generation of reactive oxygen species (ROS). NOX2 activity is central to redox signaling...
3.
DeVallance E, Dustin C, de Jesus D, Al Ghouleh I, Sembrat J, Cifuentes-Pagano E, et al.
Antioxidants (Basel)
. 2023 Jan;
12(1).
PMID: 36670936
Pulmonary arterial hypertension (PAH) is a rare yet devastating and incurable disease with few treatment options. The underlying mechanisms of PAH appear to involve substantial cellular proliferation and vascular remodeling,...
4.
Morris C, Habibovic A, Dustin C, Schiffers C, Lin M, Ather J, et al.
Mucosal Immunol
. 2022 Jun;
15(5):977-989.
PMID: 35654836
The NADPH oxidase DUOX1 contributes to epithelial production of alarmins, including interleukin (IL)-33, in response to injurious triggers such as airborne protease allergens, and mediates development of mucus metaplasia and...
5.
Li Y, Kracun D, Dustin C, El Massry M, Yuan S, Goossen C, et al.
Proc Natl Acad Sci U S A
. 2021 Oct;
118(42).
PMID: 34654740
In an aging population, intense interest has shifted toward prolonging health span. Mounting evidence suggests that cellular reactive species are propagators of cell damage, inflammation, and cellular senescence. Thus, such...
6.
Dustin C, Habibovic A, Hristova M, Schiffers C, Morris C, Lin M, et al.
J Immunol
. 2021 Jun;
206(12):2989-2999.
PMID: 34088769
The respiratory epithelium forms the first line of defense against inhaled pathogens and acts as an important source of innate cytokine responses to environmental insults. One critical mediator of these...
7.
Schiffers C, Lundblad L, Hristova M, Habibovic A, Dustin C, Daphtary N, et al.
Am J Physiol Lung Cell Mol Physiol
. 2021 May;
321(1):L144-L158.
PMID: 33951398
Aging is associated with a gradual loss of lung function due to increased cellular senescence, decreased regenerative capacity, and impaired innate host defense. One important aspect of innate airway epithelial...
8.
Veith C, Hristova M, Danyal K, Habibovic A, Dustin C, McDonough J, et al.
Am J Physiol Lung Cell Mol Physiol
. 2020 Dec;
320(3):L356-L367.
PMID: 33325804
Idiopathic pulmonary fibrosis (IPF) is characterized by a disturbed redox balance and increased production of reactive oxygen species (ROS), which is believed to contribute to epithelial injury and fibrotic lung...
9.
Schiffers C, van de Wetering C, Bauer R, Habibovic A, Hristova M, Dustin C, et al.
JCI Insight
. 2020 Dec;
6(2).
PMID: 33301419
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by small airway remodeling and alveolar emphysema due to environmental stresses such as cigarette smoking (CS). Oxidative stress is...
10.
Schiffers C, Hristova M, Habibovic A, Dustin C, Danyal K, Reynaert N, et al.
Am J Respir Cell Mol Biol
. 2020 Mar;
63(2):198-208.
PMID: 32182090
The airway epithelium plays a critical role in innate responses to airborne allergens by secreting IL-1 family cytokines such as IL-1α and IL-33 as alarmins that subsequently orchestrate appropriate immune...