Christopher L Plaisier
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Explore the profile of Christopher L Plaisier including associated specialties, affiliations and a list of published articles.
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36
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4132
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Recent Articles
11.
Kuppers D, Arora S, Lim Y, Lim A, Carter L, Corrin P, et al.
Nat Commun
. 2019 Oct;
10(1):4596.
PMID: 31601799
Many of the regulatory features governing erythrocyte specification, maturation, and associated disorders remain enigmatic. To identify new regulators of erythropoiesis, we utilize a functional genomic screen for genes affecting expression...
12.
Thorsson V, Gibbs D, Brown S, Wolf D, Bortone D, Yang T, et al.
Immunity
. 2019 Aug;
51(2):411-412.
PMID: 31433971
No abstract available.
13.
Thorsson V, Gibbs D, Brown S, Wolf D, Bortone D, Yang T, et al.
Immunity
. 2018 Apr;
48(4):812-830.e14.
PMID: 29628290
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identified six immune subtypes-wound...
14.
Keller M, Paul P, Rabaglia M, Stapleton D, Schueler K, Broman A, et al.
PLoS Genet
. 2016 Dec;
12(12):e1006466.
PMID: 27935966
Human genome-wide association studies (GWAS) have shown that genetic variation at >130 gene loci is associated with type 2 diabetes (T2D). We asked if the expression of the candidate T2D-associated...
15.
Plaisier C, OBrien S, Bernard B, Reynolds S, Simon Z, Toledo C, et al.
Cell Syst
. 2016 Jul;
3(2):172-186.
PMID: 27426982
We developed the transcription factor (TF)-target gene database and the Systems Genetics Network Analysis (SYGNAL) pipeline to decipher transcriptional regulatory networks from multi-omic and clinical patient data, and we applied...
16.
Toledo C, Ding Y, Hoellerbauer P, Davis R, Basom R, Girard E, et al.
Cell Rep
. 2015 Dec;
13(11):2425-2439.
PMID: 26673326
To identify therapeutic targets for glioblastoma (GBM), we performed genome-wide CRISPR-Cas9 knockout (KO) screens in patient-derived GBM stem-like cells (GSCs) and human neural stem/progenitors (NSCs), non-neoplastic stem cell controls, for...
17.
Danziger S, Reiss D, Ratushny A, Smith J, Plaisier C, Aitchison J, et al.
BMC Syst Biol
. 2015 Apr;
9 Suppl 2:S1.
PMID: 25881257
Background: Biclustering is a popular method for identifying under which experimental conditions biological signatures are co-expressed. However, the general biclustering problem is NP-hard, offering room to focus algorithms on specific...
18.
Reiss D, Plaisier C, Wu W, Baliga N
Nucleic Acids Res
. 2015 Apr;
43(13):e87.
PMID: 25873626
The cMonkey integrated biclustering algorithm identifies conditionally co-regulated modules of genes (biclusters). cMonkey integrates various orthogonal pieces of information which support evidence of gene co-regulation, and optimizes biclusters to be...
19.
Plaisier C, Lo F, Ashworth J, Brooks A, Beer K, Kaur A, et al.
BMC Syst Biol
. 2014 Nov;
8:122.
PMID: 25394904
Background: Expansion of transcription factors is believed to have played a crucial role in evolution of all organisms by enabling them to deal with dynamic environments and colonize new environments....
20.
Ashworth J, Bernard B, Reynolds S, Plaisier C, Shmulevich I, Baliga N
Nucleic Acids Res
. 2014 Nov;
42(21):12973-83.
PMID: 25378323
Thousands of unique mutations in transcription factors (TFs) arise in cancers, and the functional and biological roles of relatively few of these have been characterized. Here, we used structure-based methods...