Christopher L Plaisier
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Explore the profile of Christopher L Plaisier including associated specialties, affiliations and a list of published articles.
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36
Citations
4132
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Recent Articles
1.
OConnor S, Garcia L, Hoover R, Patel A, Bartelle B, Hugnot J, et al.
bioRxiv
. 2024 Apr;
PMID: 38659838
Single-cell transcriptomics has unveiled a vast landscape of cellular heterogeneity in which the cell cycle is a significant component. We trained a high-resolution cell cycle classifier (ccAFv2) using single cell...
2.
Lewis E, Mao L, Wang L, Swanson K, Barajas R, Li J, et al.
medRxiv
. 2024 Jan;
PMID: 38168377
Magnetic resonance imaging (MRI) measurements are routinely collected during the treatment of high-grade gliomas (HGGs) to characterize tumor boundaries and guide surgical tumor resection. Using spatially matched MRI and transcriptomics...
3.
Hu L, DAngelo F, Weiskittel T, Caruso F, Fortin Ensign S, Blomquist M, et al.
Nat Commun
. 2023 Sep;
14(1):6066.
PMID: 37770427
Sampling restrictions have hindered the comprehensive study of invasive non-enhancing (NE) high-grade glioma (HGG) cell populations driving tumor progression. Here, we present an integrated multi-omic analysis of spatially matched molecular...
4.
Elson D, Nguyen B, Korjeff N, Wilferd S, Puig-Sanvicens V, Jang H, et al.
Biochem Pharmacol
. 2023 Jul;
215:115706.
PMID: 37506922
Triple-negative breast cancer (TNBC) represents around 15% of the 2.26 million breast cancers diagnosed worldwide annually and has the worst outcome. Despite recent therapeutic advances, there remains a lack of...
5.
Elson D, Nguyen B, Bernales S, Chakravarty S, Jang H, Korjeff N, et al.
ACS Pharmacol Transl Sci
. 2023 Jul;
6(7):1028-1042.
PMID: 37470014
Triple-negative breast cancer (TNBC) remains a disease with a paucity of targeted treatment opportunities. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is involved in a wide...
6.
Striker S, Wilferd S, Lewis E, OConnor S, Plaisier C
Cell Rep Methods
. 2023 May;
3(4):100442.
PMID: 37159661
Somatic mutations occur as random genetic changes in genes through protein-affecting mutations (PAMs), gene fusions, or copy number alterations (CNAs). Mutations of different types can have a similar phenotypic effect...
7.
Andre A, Rees K, OConnor S, Severson G, Newbern J, Wilson-Rawls J, et al.
Front Cell Dev Biol
. 2023 Apr;
11:1084068.
PMID: 37051469
The expression of proinflammatory signals at the site of muscle injury are essential for efficient tissue repair and their dysregulation can lead to inflammatory myopathies. Macrophages, neutrophils, and fibroadipogenic progenitor...
8.
Eshima J, OConnor S, Marschall E, Bowser R, Plaisier C, Smith B
Nat Commun
. 2023 Jan;
14(1):95.
PMID: 36609402
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease with poorly understood clinical heterogeneity, underscored by significant differences in patient age at onset, symptom progression, therapeutic response, disease duration, and comorbidity...
9.
Lo Cascio C, McNamara J, Melendez E, Lewis E, Dufault M, Sanai N, et al.
JCI Insight
. 2021 Sep;
6(17).
PMID: 34494550
Glioblastoma (GBM) is characterized by an aberrant yet druggable epigenetic landscape. One major family of epigenetic regulators, the histone deacetylases (HDACs), are considered promising therapeutic targets for GBM due to...
10.
OConnor S, Feldman H, Arora S, Hoellerbauer P, Toledo C, Corrin P, et al.
Mol Syst Biol
. 2021 Jun;
17(6):e9522.
PMID: 34101353
Single-cell RNA sequencing has emerged as a powerful tool for resolving cellular states associated with normal and maligned developmental processes. Here, we used scRNA-seq to examine the cell cycle states...