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Christopher K Macgowan

Explore the profile of Christopher K Macgowan including associated specialties, affiliations and a list of published articles. Areas
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Articles 115
Citations 1265
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Recent Articles
1.
Goolaub D, Tian Y, van Amerom J, Wood J, Detterich J, Nayak K, et al.
J Cardiovasc Magn Reson . 2025 Feb; :101856. PMID: 39923939
Background: Dynamic fetal cardiovascular MRI (CMR) enables visualization of moving structures to assess congenital heart disease and plan treatment. Low field MRI systems can provide more comfortable platforms for fetal...
2.
Cho S, Darby J, Saini B, Holman S, Lock M, Perumal S, et al.
J Physiol . 2024 Nov; 602(24):7065-7083. PMID: 39549304
Programming effects of maternal undernutrition on fetal metabolic and cardiovascular systems are well elucidated, yet a detailed characterization of maternal haemodynamics is not available. This study used comprehensive cardiovascular magnetic...
3.
Huynh C, Goolaub D, Macgowan C
Sci Rep . 2024 Oct; 14(1):24084. PMID: 39406755
A novel method for creating "golden" 3D center-out radial MRI sampling trajectories was developed and analyzed. This method, called ELECTRO (ELECTRic potential energy Optimized), uses repulsive forces to minimize electric...
4.
Sadiku E, Sun L, Macgowan C, Seed M, Morrison J
Front Cardiovasc Med . 2024 Aug; 11:1426593. PMID: 39108671
Placental function plays a crucial role in fetal development, as it serves as the primary interface for delivery of nutrients and oxygen from the mother to fetus. Magnetic resonance imaging...
5.
Cho S, Darby J, Williams G, Holman S, Rai A, van Amerom J, et al.
J Magn Reson Imaging . 2024 Jun; 61(3):1323-1335. PMID: 38940396
Background: Cardiac MRI feature tracking (FT) allows objective assessment of segmental left ventricular (LV) function following a myocardial infarction (MI), but its utilization in sheep, where interventions can be tested,...
6.
Darby J, Saini B, Holman S, Hammond S, Perumal S, Macgowan C, et al.
Front Med (Lausanne) . 2024 Jun; 11:1340012. PMID: 38933113
Introduction: The fetal haemodynamic response to acute episodes of hypoxaemia are well characterised. However, how these responses change when the hypoxaemia becomes more chronic in nature such as that associated...
7.
Darby J, Flouri D, Cho S, Williams G, Holman S, Meakin A, et al.
Exp Physiol . 2024 Apr; 109(6):980-991. PMID: 38606906
Increasing placental perfusion (PP) could improve outcomes of growth-restricted fetuses. One way of increasing PP may be by using phosphodiesterase (PDE)-5 inhibitors, which induce vasodilatation of vascular beds. We used...
8.
Lee F, Sun L, van Amerom J, Portnoy S, Marini D, Saini A, et al.
J Am Coll Cardiol . 2024 Mar; 83(13):1225-1239. PMID: 38538202
Background: Fetuses with cyanotic congenital heart disease (CHD) exhibit profound fetal circulatory disturbances that may affect early outcomes. Objectives: This study sought to investigate the relationship between fetal hemodynamics and...
9.
Goolaub D, Macgowan C
J Cardiovasc Magn Reson . 2024 Jan; 26(1):101003. PMID: 38290615
Background: Non-Cartesian magnetic resonance imaging trajectories at golden angle increments have the advantage of allowing motion correction and gating using intermediate real-time reconstructions. However, when the acquired data are cardiac...
10.
Hanrahan J, Steeves K, Locke D, OBrien T, Maekawa A, Amiri R, et al.
Sci Rep . 2024 Jan; 14(1):399. PMID: 38172192
While microplastics have been recently detected in human blood and the placenta, their impact on human health is not well understood. Using a mouse model of environmental exposure during pregnancy,...