Christopher John Schlicksup
Overview
Explore the profile of Christopher John Schlicksup including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
177
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0
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Recent Articles
1.
Khaykelson D, Asor R, Zhao Z, Schlicksup C, Zlotnick A, Raviv U
Biochemistry
. 2024 May;
63(12):1543-1552.
PMID: 38787909
Hepatitis B virus (HBV) displays remarkable self-assembly capabilities that interest the scientific community and biotechnological industries as HBV is leading to an annual mortality of up to 1 million people...
2.
Schlicksup C, Zlotnick A
Curr Opin Virol
. 2020 Aug;
45:43-50.
PMID: 32777753
Viral structural proteins are emerging as effective targets for new antivirals. In a viral lifecycle, the capsid must assemble, disassemble, and respond to host proteins, all at the right time...
3.
Schlicksup C, Laughlin P, Dunkelbarger S, Wang J, Zlotnick A
ACS Chem Biol
. 2020 May;
15(6):1708-1717.
PMID: 32369333
Development of antiviral molecules that bind virion is a strategy that remains in its infancy, and the details of their mechanisms are poorly understood. Here we investigate the behavior of...
4.
Asor R, Schlicksup C, Zhao Z, Zlotnick A, Raviv U
J Am Chem Soc
. 2020 Apr;
142(17):7868-7882.
PMID: 32233479
There are ∼10 possible intermediates on the assembly path from hepatitis B capsid protein dimers to the 120-dimer capsid. If every intermediate was tested, assembly would often get stuck in...
5.
Asor R, Selzer L, Schlicksup C, Zhao Z, Zlotnick A, Raviv U
ACS Nano
. 2019 Jun;
13(7):7610-7626.
PMID: 31173689
For many viruses, capsids (biological nanoparticles) assemble to protect genetic material and dissociate to release their cargo. To understand these contradictory properties, we analyzed capsid assembly for hepatitis B virus;...
6.
Hadden J, Perilla J, Schlicksup C, Venkatakrishnan B, Zlotnick A, Schulten K
Elife
. 2018 May;
7.
PMID: 29708495
The hepatitis B virus capsid represents a promising therapeutic target. Experiments suggest the capsid must be flexible to function; however, capsid structure and dynamics have not been thoroughly characterized in...
7.
Schlicksup C, Wang J, Francis S, Venkatakrishnan B, Turner W, VanNieuwenhze M, et al.
Elife
. 2018 Jan;
7.
PMID: 29377794
Defining mechanisms of direct-acting antivirals facilitates drug development and our understanding of virus function. Heteroaryldihydropyrimidines (HAPs) inappropriately activate assembly of hepatitis B virus (HBV) core protein (Cp), suppressing formation of...