Christopher J Roberts
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Explore the profile of Christopher J Roberts including associated specialties, affiliations and a list of published articles.
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130
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4846
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Recent Articles
1.
Chrisp R, Masterson M, Pope R, Roberts C, Collins H, Watson D, et al.
Sci Rep
. 2025 Mar;
15(1):8347.
PMID: 40069567
NPAS2 (Neuronal PAS Domain Protein 2) is a component of the core circadian clock and the coordinated activity between central brain and peripheral liver clock proteins postulated to be instrumental...
2.
Roberts C, Popies J, Razzak A, Fang X, Falcucci O, Pearson P, et al.
Anaesth Intensive Care
. 2024 Oct;
52(6):386-396.
PMID: 39394874
Skin injuries are a major healthcare problem that are not well understood or prevented in the critically ill, suggesting that underappreciated variables are contributing. This pilot study tested the hypothesis...
3.
Lehmann A, Queen J, Roberts C, Rissanen K, Tuononen H, Power P
Angew Chem Int Ed Engl
. 2024 Aug;
63(52):e202412599.
PMID: 39158119
Careful analysis of the crystals formed in the reduction of ArAlI (Ar=CH-2,6-(CH-2,4,6-Pr)-3,5-Pr) with sodium on sodium chloride showed them to contain the long sought-after dialuminene ArAlAlAr (1) that forms alongside...
4.
Buckland B, Sanyal G, Ranheim T, Pollard D, Searles J, Behrens S, et al.
Biotechnol Bioeng
. 2024 May;
121(9):2604-2635.
PMID: 38711222
In the past decade, new approaches to the discovery and development of vaccines have transformed the field. Advances during the COVID-19 pandemic allowed the production of billions of vaccine doses...
5.
Palakollu V, Motabar L, Roberts C
Mol Pharm
. 2024 Feb;
21(3):1414-1423.
PMID: 38386020
Protein self-interactions measured via second osmotic virial coefficients () and dynamic light scattering interaction parameter values () are often used as metrics for assessing the favorability of protein candidates and...
6.
Forder J, Palakollu V, Adhikari S, Blanco M, Derebe M, Ferguson H, et al.
Mol Pharm
. 2024 Feb;
21(3):1321-1333.
PMID: 38334418
Attractive self-interactions and reversible self-association are implicated in many problematic solution behaviors for therapeutic proteins, such as irreversible aggregation, elevated viscosity, phase separation, and opalescence. Protein self-interactions and reversible oligomerization...
7.
Computational Screening for mAb Colloidal Stability with Coarse-Grained, Molecular-Scale Simulations
Janke J, Starr C, Kingsbury J, Furtmann N, Roberts C, Calero-Rubio C
J Phys Chem B
. 2024 Feb;
128(6):1515-1526.
PMID: 38315822
Monoclonal antibodies (mAbs) are an important modality of protein therapeutics with broad applications for numerous diseases. However, colloidal instabilities occurring at high protein concentrations can limit the ability to develop...
8.
Roberts C, Barber J, Temkin N, Dong A, Robertson C, Valadka A, et al.
JAMA Surg
. 2023 Dec;
159(3):248-259.
PMID: 38091011
Importance: Traumatic brain injury (TBI) is associated with persistent functional and cognitive deficits, which may be susceptible to secondary insults. The implications of exposure to surgery and anesthesia after TBI...
9.
Berger J, Teixeira S, Sloey C, Qi W, Roberts C
J Phys Chem B
. 2023 Jun;
127(26):5742-5754.
PMID: 37345852
There is interest in the direct measurement of protein aggregation and reversible protein-protein interactions at high pressure as a means to assess protein stability. This is currently limited by the...
10.
Wood C, Razinkov V, Qi W, Roberts C, Vermant J, Furst E
Langmuir
. 2023 May;
39(22):7775-7782.
PMID: 37222141
When monoclonal antibodies are exposed to an air-water interface, they form aggregates, which negatively impacts their performance. Until now, the detection and characterization of interfacial aggregation have been difficult. Here,...