Christopher J Ormandy
Overview
Explore the profile of Christopher J Ormandy including associated specialties, affiliations and a list of published articles.
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74
Citations
2839
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Recent Articles
1.
Law A, Chen J, Colino-Sanguino Y, Rodriguez de la Fuente L, Fang G, Grimes S, et al.
Adv Sci (Weinh)
. 2022 May;
9(21):e2103332.
PMID: 35611998
To fully investigate cellular responses to stimuli and perturbations within tissues, it is essential to replicate the complex molecular interactions within the local microenvironment of cellular niches. Here, the authors...
2.
Ho W, Law A, Masle-Farquhar E, Castillo L, Mawson A, OBryan M, et al.
Breast Cancer Res
. 2022 May;
24(1):31.
PMID: 35505346
Background: The interferon response can influence the primary and metastatic activity of breast cancers and can interact with checkpoint immunotherapy to modulate its effects. Using N-ethyl-N-nitrosourea mutagenesis, we found a...
3.
Sun Y, Yang N, Utama F, Udhane S, Zhang J, Peck A, et al.
Sci Adv
. 2021 Sep;
7(38):eabc8145.
PMID: 34524841
Most breast cancer deaths are caused by estrogen receptor-α–positive (ER) disease. Preclinical progress is hampered by a shortage of therapy-naïve ER tumor models that recapitulate metastatic progression and clinically relevant...
4.
Holliday H, Roden D, Junankar S, Wu S, Baker L, Krisp C, et al.
iScience
. 2021 Feb;
24(2):102072.
PMID: 33554073
Inhibitor of differentiation (ID) proteins dimerize with basic HLH (bHLH) transcription factors, repressing transcription of lineage-specification genes across diverse cellular lineages. ID4 is a key regulator of mammary stem cells;...
5.
Teo W, Holliday H, Karthikeyan N, Cazet A, Roden D, Harvey K, et al.
Front Cell Dev Biol
. 2020 Aug;
8:552.
PMID: 32766238
Breast cancers display phenotypic and functional heterogeneity and several lines of evidence support the existence of cancer stem cells (CSCs) in certain breast cancers, a minor population of cells capable...
6.
Baker L, Holliday H, Roden D, Krisp C, Wu S, Junankar S, et al.
Breast Cancer Res
. 2020 Jun;
22(1):63.
PMID: 32527287
Background: Basal-like breast cancer (BLBC) is a poorly characterised, heterogeneous disease. Patients are diagnosed with aggressive, high-grade tumours and often relapse with chemotherapy resistance. Detailed understanding of the molecular underpinnings...
7.
Piggin C, Roden D, Law A, Molloy M, Krisp C, Swarbrick A, et al.
PLoS Genet
. 2020 Jan;
16(1):e1008531.
PMID: 31895944
Acquired resistance to endocrine therapy is responsible for half of the therapeutic failures in the treatment of breast cancer. Recent findings have implicated increased expression of the ETS transcription factor...
8.
Castillo L, Young A, Mawson A, Schafranek P, Steinmann A, Nessem D, et al.
Oncogene
. 2019 Nov;
39(8):1821-1829.
PMID: 31735913
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies. It is phenotypically heterogeneous with a highly unstable genome and provides few common therapeutic targets. We found that MCL1, Cofilin1...
9.
Valdes-Mora F, Handler K, Law A, Salomon R, Oakes S, Ormandy C, et al.
Front Immunol
. 2018 Nov;
9:2582.
PMID: 30483257
Cancer is a heterogeneous and complex disease. Tumors are formed by cancer cells and a myriad of non-cancerous cell types that together with the extracellular matrix form the tumor microenvironment....
10.
Hassanzadeh-Barforoushi A, Law A, Hejri A, Asadnia M, Ormandy C, Gallego-Ortega D, et al.
Lab Chip
. 2018 Jun;
18(15):2156-2166.
PMID: 29922784
We present here a new method to easily and reliably generate an array of hundreds of dispersed nanoliter-volume semi-droplets for single-cells culture and analysis. The liquid segmentation step occurs directly...