Christopher Hakkaart
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Explore the profile of Christopher Hakkaart including associated specialties, affiliations and a list of published articles.
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8
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70
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Recent Articles
1.
Chen Y, Davidson N, Kei Wan Y, Yao F, Su Y, Gamaarachchi H, et al.
Nat Methods
. 2025 Mar;
PMID: 40082608
The human genome contains instructions to transcribe more than 200,000 RNAs. However, many RNA transcripts are generated from the same gene, resulting in alternative isoforms that are highly similar and...
2.
Kishore A, Sturm M, Pillai K, Hakkaart C, Puthanveedu D, Urulangodi M, et al.
NPJ Parkinsons Dis
. 2024 Apr;
10(1):85.
PMID: 38622158
The genetic loci implicated in familial Parkinson's disease (PD) have limited generalizability to the Indian PD population. We tested mutations and the frequency of known mutations in the SNCA gene...
3.
Hakkaart C, Pearson J, Marquart L, Dennis J, Wiggins G, Barnes D, et al.
Commun Biol
. 2022 Oct;
5(1):1061.
PMID: 36203093
The contribution of germline copy number variants (CNVs) to risk of developing cancer in individuals with pathogenic BRCA1 or BRCA2 variants remains relatively unknown. We conducted the largest genome-wide analysis...
4.
Aitchison A, Hakkaart C, Day R, Morrin H, Frizelle F, Keenan J
Cancers (Basel)
. 2020 Dec;
12(12).
PMID: 33352971
While overall colorectal cancer (CRC) cases have been declining worldwide there has been an increase in the incidence of the disease among patients under 50 years of age. Mutation of...
5.
Aitchison A, Hakkaart C, Whitehead M, Khan S, Siddique S, Ahmed R, et al.
Pathol Res Pract
. 2020 Mar;
216(5):152912.
PMID: 32147272
Aim: Colorectal signet-ring cell carcinomas (SRCC) are highly malignant tumours with poor prognosis that disproportionately affect younger patients. There is growing evidence of a unique set of molecular features that...
6.
Walker L, Lattimore V, Kvist A, Kleiblova P, Zemankova P, de Jong L, et al.
Front Genet
. 2019 Dec;
10:1139.
PMID: 31803232
Case-control analyses have shown variants to be associated with up to >2-fold increase in risk of breast cancer, and potentially greater risk of triple negative breast cancer. is included in...
7.
Norero E, Alarcon M, Hakkaart C, de Mayo T, Mellado C, Garrido M, et al.
Int J Mol Sci
. 2019 Oct;
20(20).
PMID: 31600923
Germline pathogenic variants in the gene are a well-established cause of hereditary diffuse gastric cancer (HDGC) syndrome. The aim of this study was to characterize mutations associated with HDGC from...
8.
Bougen-Zhukov N, Nouri Y, Godwin T, Taylor M, Hakkaart C, Single A, et al.
Cancers (Basel)
. 2019 Sep;
11(9).
PMID: 31540244
The gene, encoding the cell adhesion protein E-cadherin, is one of the most frequently mutated genes in gastric cancer and inactivating germline mutations are responsible for hereditary diffuse gastric cancer...
9.
Hakkaart C, Ellison-Loschmann L, Day R, Sporle A, Koea J, Harawira P, et al.
Fam Cancer
. 2018 Mar;
18(1):83-90.
PMID: 29589180
New Zealand Māori have a considerably higher incidence of gastric cancer compared to non-Māori, and are one of the few populations worldwide with a higher prevalence of diffuse-type disease. Pathogenic...