Christopher DeBoever
Overview
Explore the profile of Christopher DeBoever including associated specialties, affiliations and a list of published articles.
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Articles
20
Citations
806
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0
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Recent Articles
1.
Microprotein-encoding RNA regulation in cells treated with pro-inflammatory and pro-fibrotic stimuli
Pai V, Lau C, Garcia-Ruiz A, Donaldson C, Vaughan J, Miller B, et al.
BMC Genomics
. 2024 Nov;
25(1):1034.
PMID: 39497054
Background: Recent analysis of the human proteome via proteogenomics and ribosome profiling of the transcriptome revealed the existence of thousands of previously unannotated microprotein-coding small open reading frames (smORFs). Most...
2.
Parikh V, Ioannidis A, Jimenez-Morales D, Gorzynski J, De Jong H, Liu X, et al.
Nat Commun
. 2022 Aug;
13(1):5107.
PMID: 36042219
The SARS-CoV-2 pandemic has differentially impacted populations across race and ethnicity. A multi-omic approach represents a powerful tool to examine risk across multi-ancestry genomes. We leverage a pandemic tracking strategy...
3.
Venkataraman G, DeBoever C, Tanigawa Y, Aguirre M, Ioannidis A, Mostafavi H, et al.
Am J Hum Genet
. 2021 Nov;
108(12):2354-2367.
PMID: 34822764
Whole-genome sequencing studies applied to large populations or biobanks with extensive phenotyping raise new analytic challenges. The need to consider many variants at a locus or group of genes simultaneously...
4.
Jakubosky D, Smith E, DAntonio M, Bonder M, Greenwald W, DAntonio-Chronowska A, et al.
Nat Commun
. 2020 Jun;
11(1):2928.
PMID: 32522985
Structural variants (SVs) and short tandem repeats (STRs) are important sources of genetic diversity but are not routinely analyzed in genetic studies because they are difficult to accurately identify and...
5.
Jakubosky D, DAntonio M, Bonder M, Smail C, Donovan M, Greenwald W, et al.
Nat Commun
. 2020 Jun;
11(1):2927.
PMID: 32522982
Structural variants (SVs) and short tandem repeats (STRs) comprise a broad group of diverse DNA variants which vastly differ in their sizes and distributions across the genome. Here, we identify...
6.
DeBoever C, Tanigawa Y, Aguirre M, McInnes G, Lavertu A, Rivas M
Am J Hum Genet
. 2020 Apr;
106(5):611-622.
PMID: 32275883
Population-scale biobanks that combine genetic data and high-dimensional phenotyping for a large number of participants provide an exciting opportunity to perform genome-wide association studies (GWAS) to identify genetic variants associated...
7.
Benaglio P, DAntonio-Chronowska A, Ma W, Yang F, Greenwald W, Donovan M, et al.
Nat Genet
. 2019 Oct;
51(10):1506-1517.
PMID: 31570892
The cardiac transcription factor (TF) gene NKX2-5 has been associated with electrocardiographic (EKG) traits through genome-wide association studies (GWASs), but the extent to which differential binding of NKX2-5 at common...
8.
Tanigawa Y, Li J, Justesen J, Horn H, Aguirre M, DeBoever C, et al.
Nat Commun
. 2019 Sep;
10(1):4064.
PMID: 31492854
Population-based biobanks with genomic and dense phenotype data provide opportunities for generating effective therapeutic hypotheses and understanding the genomic role in disease predisposition. To characterize latent components of genetic associations,...
9.
DeBoever C, Tanigawa Y, Lindholm M, McInnes G, Lavertu A, Ingelsson E, et al.
Nat Commun
. 2018 Apr;
9(1):1612.
PMID: 29691392
Protein-truncating variants can have profound effects on gene function and are critical for clinical genome interpretation and generating therapeutic hypotheses, but their relevance to medical phenotypes has not been systematically...
10.
Nariai N, Greenwald W, DeBoever C, Li H, Frazer K
Genetics
. 2017 Oct;
207(4):1301-1312.
PMID: 29074555
Expression quantitative trait loci (eQTL) studies have typically used single-variant association analysis to identify genetic variants correlated with gene expression. However, this approach has several drawbacks: causal variants cannot be...