Christopher D Utzat
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Explore the profile of Christopher D Utzat including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
79
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Recent Articles
1.
Mutagenicity of the 1-nitropyrene-DNA adduct N-(deoxyguanosin-8-yl)-1-aminopyrene in mammalian cells
Watt D, Utzat C, Hilario P, Basu A
Chem Res Toxicol
. 2007 Oct;
20(11):1658-64.
PMID: 17907783
The mutagenesis of the major DNA adduct N-(deoxyguanosin-8-yl)-1-aminopyrene (C8-AP-dG) formed by 1-nitropyrene was compared with the analogous C8-dG adducts of 2-aminofluorene (AF) and N-acetyl-2-aminofluorene (AAF) in simian kidney (COS-7) cells....
2.
Utzat C, Clement C, Ramos L, Das A, Tomasz M, Basu A
Chem Res Toxicol
. 2005 Feb;
18(2):213-23.
PMID: 15720125
Mitomycin C (MC) is a cytotoxic and mutagenic antitumor agent that alkylates and cross-links DNA. These effects are dependent on reductive bioactivation of MC. 2,7-Diaminomitosene (2,7-DAM) is the major metabolite...
3.
Liu Y, Yang Z, Utzat C, Liu Y, Geacintov N, Basu A, et al.
Biochem J
. 2004 Sep;
385(Pt 2):519-26.
PMID: 15362978
Human RPA (replication protein A), a single-stranded DNA-binding protein, is required for many cellular pathways including DNA repair, recombination and replication. However, the role of RPA in nucleotide excision repair...
4.
Zou Y, Shell S, Utzat C, Luo C, Yang Z, Geacintov N, et al.
Biochemistry
. 2003 Oct;
42(43):12654-61.
PMID: 14580212
DNA damage recognition of nucleotide excision repair (NER) in Escherichia coli is achieved by at least two steps. In the first step, a helical distortion is recognized, which leads to...