Ashis K Basu
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Explore the profile of Ashis K Basu including associated specialties, affiliations and a list of published articles.
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71
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1190
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Recent Articles
1.
Dasgupta S, Gao S, Yang H, Greenberg M, Basu A
Chem Res Toxicol
. 2024 Jul;
37(8):1445-1452.
PMID: 39041427
Tandem lesions, which are defined by two or more contiguously damaged nucleotides, are a hallmark of ionizing radiation. Recently, tandem lesions containing 5-formyl-2'-deoxyuridine (5-fdU) flanked by a 5'-8-OxodGuo or Fapy•dG...
2.
Bacurio J, Yawson P, Thomforde J, Zhang Q, Kumar H, Den Hartog H, et al.
J Biol Chem
. 2024 Feb;
300(4):105786.
PMID: 38401843
Histone proteins can become trapped on DNA in the presence of 5-formylcytosine (5fC) to form toxic DNA-protein conjugates. Their repair may involve proteolytic digestion resulting in DNA-peptide cross-links (DpCs). Here,...
3.
Bacurio J, Gao S, Yang H, Basu A, Greenberg M
DNA Repair (Amst)
. 2023 Jul;
129:103527.
PMID: 37467631
Modified nucleotides often hinder and/or decrease the fidelity of DNA polymerases. Tandem lesions, which are comprised of DNA modifications at two contiguous nucleotide positions, can be even more detrimental to...
4.
Stanio S, Bacurio J, Yang H, Greenberg M, Basu A
Chem Res Toxicol
. 2023 Apr;
36(5):782-789.
PMID: 37093780
7,8-Dihydro-8-oxo-2'-deoxyguanosine (8-OxodGuo) is a ubiquitous DNA damage formed by oxidation of 2'-deoxyguanosine. In this study, plasmid DNA containing 8-OxodGuo located in three mutational hot spots of human cancers, codons 248,...
5.
Basu A, Essigmann J
Chem Res Toxicol
. 2022 Jul;
35(10):1655-1675.
PMID: 35881568
DNA damage by chemicals, radiation, or oxidative stress leads to a mutational spectrum, which is complex because it is determined in part by lesion structure, the DNA sequence context of...
6.
Ryan B, Yang H, Bacurio J, Smith M, Basu A, Greenberg M, et al.
J Am Chem Soc
. 2022 May;
144(18):8054-8065.
PMID: 35499923
6-(2-Deoxy-α,β-d--pentofuranosyl)-2,6-diamino-4-hydroxy-5-formamido pyrimidine (Fapy•dG) is a prevalent form of genomic DNA damage. Fapy•dG is formed in greater amounts under anoxic conditions than the well-studied, chemically related 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-oxodGuo). Fapy•dG is more...
7.
Bacurio J, Yang H, Naldiga S, Powell B, Ryan B, Freudenthal B, et al.
DNA Repair (Amst)
. 2021 Aug;
108:103213.
PMID: 34464900
Fapy•dG and 8-OxodGuo are formed in DNA from a common N7-dG radical intermediate by reaction with hydroxyl radical. Although cellular levels of Fapy•dG are often greater, its effects on replication...
8.
Powell B, Bacurio J, Basu A
DNA Repair (Amst)
. 2020 Jul;
95:102935.
PMID: 32721818
6-Nitrochrysene (6-NC) is a potent mutagen in bacteria and carcinogenic in animals. It is the most potent carcinogen ever tested in newborn mouse assay. DNA lesions resulting from 6-NC modification...
9.
Pande P, Rebello K, Chatterjee A, Naldiga S, Basu A
Chem Res Toxicol
. 2020 Jun;
33(7):1997-2005.
PMID: 32551527
The environmental pollutant 6-nitrochrysene (6-NC) is a potent mutagen and a mammary carcinogen in rats. 6-NC is the most potent carcinogen ever tested in the newborn mouse assay. In mammalian...
10.
Powell B, Basu A
Chem Res Toxicol
. 2020 Jan;
33(2):604-613.
PMID: 31903755
6-Nitrochrysene (6-NC), the most potent carcinogen evaluated by the newborn mouse assay, is metabolically activated by nitroreduction and a combination of ring oxidation and nitroreduction pathways. The nitroreduction pathway yields...