Christopher D Chien
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Explore the profile of Christopher D Chien including associated specialties, affiliations and a list of published articles.
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21
Citations
790
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Recent Articles
11.
Jacoby E, Chien C, Fry T
Front Oncol
. 2014 May;
4:95.
PMID: 24847444
Leukemia remains the most common diagnosis in pediatric oncology and, despite dramatic progress in upfront therapy, is also the most common cause of cancer-related death in children. Much of the...
12.
Garee J, Chien C, Li J, Wellstein A, Riegel A
Mol Endocrinol
. 2014 Apr;
28(6):846-59.
PMID: 24678732
Transcription of the HER2 oncogene can be repressed by estrogen (E2). We now show that, a splice isoform of the nuclear receptor coactivator AIB1, AIB1-Δ4, is able to reverse E2...
13.
Li J, Chien C, Garee J, Xu J, Wellstein A, Riegel A
Mol Endocrinol
. 2013 May;
27(7):1113-27.
PMID: 23660594
The oncogene nuclear receptor coactivator amplified in breast cancer 1 (AIB1) is a transcriptional coactivator that is overexpressed in various types of human cancers. However, the molecular mechanisms controlling AIB1...
14.
Ullmann R, Chien C, Avantaggiati M, Muller S
Mol Cell
. 2012 May;
46(6):759-70.
PMID: 22578841
The attachment of the SUMO modifier to proteins controls cellular signaling pathways through noncovalent binding to SUMO-interaction motifs (SIMs). Canonical SIMs contain a core of hydrophobic residues that bind to...
15.
Chien C, Kirilyuk A, Li J, Zhang W, Lahusen T, Schmidt M, et al.
J Biol Chem
. 2011 Jun;
286(30):26813-27.
PMID: 21636853
The oncogene amplified in breast cancer 1 (AIB1) is a nuclear receptor coactivator that plays a major role in the progression of various cancers. We previously identified a splice variant...
16.
Oh A, Lahusen J, Chien C, Fereshteh M, Zhang X, Dakshanamurthy S, et al.
Mol Cell Biol
. 2008 Sep;
28(21):6580-93.
PMID: 18765637
Overexpression and activation of the steroid receptor coactivator amplified in breast cancer 1 (AIB1)/steroid receptor coactivator-3 (SRC-3) have been shown to have a critical role in oncogenesis and are required...
17.
Kochenderfer J, Chien C, Simpson J, Gress R
Clin Immunol
. 2007 Jun;
124(2):119-30.
PMID: 17584532
We assessed the ability of several factors to increase the size of tumor-antigen-specific CD8(+) T cell responses elicited by vaccines incorporating peptides and CpG-containing oligodeoxynucleotides (CpG). Neither granulocyte-macrophage colony-stimulating factor...
18.
Kochenderfer J, Simpson J, Chien C, Gress R
Blood
. 2007 Mar;
110(1):450-60.
PMID: 17371943
Development of CD8(+) T-cell responses targeting tumor-associated antigens after autologous stem cell transplantations (ASCTs) might eradicate residual tumor cells and decrease relapse rates. Because thymic function dramatically decreases with aging,...
19.
Kochenderfer J, Chien C, Simpson J, Gress R
J Immunol
. 2006 Dec;
177(12):8860-73.
PMID: 17142789
Novel anticancer vaccination regimens that can elicit large numbers of Ag-specific T cells are needed. When we administered therapeutic vaccines containing the MHC class I-presented self-peptide tyrosinase-related protein (TRP)-2(180-188) and...
20.
Worth R, Chien C, Chien P, Reilly M, McKenzie S, Schreiber A
Exp Hematol
. 2006 Oct;
34(11):1490-5.
PMID: 17046568
Objective: The physiologic role of platelet FcgammaRIIA, the only Fc receptor for IgG on human platelets, is largely unknown. FcgammaRIIA is also expressed on phagocytes such as monocytes and neutrophils,...