Christopher Capp
Overview
Explore the profile of Christopher Capp including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
127
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0
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Recent Articles
1.
RHINO forms a stoichiometric complex with the 9-1-1 checkpoint clamp and mediates ATR-Chk1 signaling
Lindsey-Boltz L, Kemp M, Capp C, Sancar A
Cell Cycle
. 2015 Jan;
14(1):99-108.
PMID: 25602520
The ATR-Chk1 signaling pathway mediates cellular responses to DNA damage and replication stress and is composed of a number of core factors that are conserved throughout eukaryotic organisms. However, humans...
2.
Capp C, Qian Y, Sage H, Huber H, Hsieh T
J Biol Chem
. 2010 Oct;
285(51):39637-45.
PMID: 20929866
Reverse gyrase reanneals denatured DNA and induces positive supercoils in DNA, an activity that is critical for life at very high temperatures. Positive supercoiling occurs by a poorly understood mechanism...
3.
Capp C, Wu J, Hsieh T
Crit Rev Biochem Mol Biol
. 2010 May;
45(3):233-42.
PMID: 20429771
Recent work has greatly contributed to the understanding of the biology and biochemistry of RecQ4. It plays an essential non-enzymatic role in the formation of the CMG complex, and thus...
4.
Capp C, Wu J, Hsieh T
J Biol Chem
. 2009 Sep;
284(45):30845-52.
PMID: 19759018
Members of the RecQ family of proteins are highly conserved DNA helicases that have important functions in the maintenance of genomic stability. Deficiencies in RecQ4 have been linked to human...
5.
Wu J, Capp C, Feng L, Hsieh T
Dev Biol
. 2008 Aug;
323(1):130-42.
PMID: 18755177
Members of the RecQ family play critical roles in maintaining genome integrity. Mutations in human RecQL4 cause a rare genetic disorder, Rothmund-Thomson syndrome. Transgenic mice experiments showed that the RecQ4...
6.
Hsieh T, Capp C
J Biol Chem
. 2005 Mar;
280(21):20467-75.
PMID: 15788400
Reverse gyrase is a unique type IA topoisomerase that can introduce positive supercoils into DNA. We have investigated some of the biochemical properties of Archaeoglobus fulgidus reverse gyrase. It can...
7.
Rendell M, Johnson M, Smith D, Finney D, Capp C, Lammers R, et al.
J Surg Res
. 2002 Oct;
107(1):18-26.
PMID: 12384060
Background: Although the microvascular blood flow response to wounding is predominantly vasodilation at skin sites with nutritive capillary perfusion (NUTR), there is a significant vasoconstrictive response at sites with high...