Christopher A Parks
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Explore the profile of Christopher A Parks including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
93
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Recent Articles
1.
Nelson A, Wang L, Laffey K, Becher L, Parks C, Hoffmann M, et al.
Front Immunol
. 2024 Sep;
15:1434463.
PMID: 39281668
Functionally bivalent non-covalent Fab dimers (Bi-Fabs) specific for the TCR/CD3 complex promote CD3 signaling on T cells. While comparing functional responses to stimulation with Bi-Fab, F(ab')2 or mAb specific for...
2.
Laffey K, Stiles R, Ludescher M, Davis T, Khwaja S, Bram R, et al.
Proc Natl Acad Sci U S A
. 2022 Jun;
119(27):e2118529119.
PMID: 35767640
During normal T cell development in mouse and human, a low-frequency population of immature CD4CD8 double-negative (DN) thymocytes expresses early, mature αβ T cell antigen receptor (TCR). We report that...
3.
Thapa P, Guyer R, Yang A, Parks C, Brusko T, Brusko M, et al.
Sci Immunol
. 2021 Dec;
6(66):eabj0789.
PMID: 34890254
Infants require coordinated immune responses to prevent succumbing to multiple infectious challenges during early life, particularly in the respiratory tract. The mechanisms by which infant T cells are functionally adapted...
4.
Gras-Pena R, Danzl N, Khosravi-Maharlooei M, Campbell S, Ruiz A, Parks C, et al.
J Allergy Clin Immunol
. 2021 Oct;
149(5):1755-1771.
PMID: 34695489
Background: Generation of thymic tissue from pluripotent stem cells would provide therapies for acquired and congenital thymic insufficiency states. Objectives: This study aimed to generate human thymic epithelial progenitors from...
5.
Becher L, Nevala W, Sutor S, Abergel M, Hoffmann M, Parks C, et al.
Blood Adv
. 2020 Oct;
4(21):5343-5356.
PMID: 33125463
Human cytomegalovirus (HCMV) induces long-lasting T-cell immune responses that control but do not clear infection. Typical responses involve private T-cell clones, expressing T-cell antigen receptors (TCRs) unique to a person,...
6.
Parks C, Henning K, Pavelko K, Hansen M, Van Keulen V, Reed B, et al.
Proc Natl Acad Sci U S A
. 2019 Feb;
116(8):3136-3145.
PMID: 30728302
Successful efforts to activate T cells capable of recognizing weak cancer-associated self-antigens have employed altered peptide antigens to activate T cell responses capable of cross-reacting on native tumor-associated self. A...
7.
Crosby C, Matchett W, Anguiano-Zarate S, Parks C, Weaver E, Pease L, et al.
J Virol
. 2016 Nov;
91(2).
PMID: 27807231
Importance: Most adenovirus vaccines that are being tested are replication-defective adenoviruses (RD-Ads). This work describes testing newer single-cycle adenovirus (SC-Ad) vectors that replicate transgenes to amplify protein production and immune...
8.
Hoffmann M, Molina-Mendiola C, Nelson A, Parks C, Reyes E, Hansen M, et al.
Sci Adv
. 2015 Nov;
1(9):e1500415.
PMID: 26601285
Adaptive immunity is mediated by antigen receptors that can induce weak or strong immune responses depending on the nature of the antigen that is bound. In T lymphocytes, antigen recognition...
9.
Gil-Pages M, Stiles R, Parks C, Neier S, Radulovic M, Oliveros A, et al.
Behav Brain Funct
. 2013 Aug;
9(1):35.
PMID: 23971729
Background: There is significant interest in the generation of improved assays to clearly identify experimental mice possessing functional vision, a property that could qualify mice for inclusion in behavioral and...
10.
Nelson A, Hoffmann M, Parks C, Dasari S, Schrum A, Gil D
J Biol Chem
. 2012 Oct;
287(51):42936-50.
PMID: 23109335
Generated by proteolytic cleavage of immunoglobulin, Fab fragments possess great promise as blocking reagents, able to bind receptors or other targets without inducing cross-linking. However, aggregation of Fab preparations is...