Christopher A Del Negro
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Explore the profile of Christopher A Del Negro including associated specialties, affiliations and a list of published articles.
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53
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Recent Articles
11.
Vann N, Pham F, Dorst K, Del Negro C
eNeuro
. 2018 May;
5(3).
PMID: 29845107
The brainstem pre-Bötzinger complex (preBötC) generates inspiratory breathing rhythms, but which neurons comprise its rhythmogenic core? Dbx1-derived neurons may play the preeminent role in rhythm generation, an idea well founded...
12.
Del Negro C, Funk G, Feldman J
Nat Rev Neurosci
. 2018 May;
19(6):351-367.
PMID: 29740175
Breathing is a well-described, vital and surprisingly complex behaviour, with behavioural and physiological outputs that are easy to directly measure. Key neural elements for generating breathing pattern are distinct, compact...
13.
Phillips W, Del Negro C, Rekling J
J Neurosci
. 2018 Feb;
38(12):3039-3049.
PMID: 29459371
The brainstem preBötzinger complex (preBötC) generates the inspiratory rhythm for breathing. The onset of neural activity that precipitates the inspiratory phase of the respiratory cycle may depend on the activity...
14.
Hayes J, Kottick A, Picardo M, Halleran A, Smith R, Smith G, et al.
Sci Rep
. 2017 Aug;
7(1):8669.
PMID: 28819234
We sequenced the transcriptome of brainstem interneurons in the specialized respiratory rhythmogenic site dubbed preBötzinger Complex (preBötC) from newborn mice. To distinguish molecular characteristics of the core oscillator we compared...
15.
Akins V, Weragalaarachchi K, Picardo M, Revill A, Del Negro C
Sci Data
. 2017 Aug;
4:170097.
PMID: 28763053
The relationship between neuron morphology and function is a perennial issue in neuroscience. Information about synaptic integration, network connectivity, and the specific roles of neuronal subpopulations can be obtained through...
16.
Fate mapping neurons and glia derived from Dbx1-expressing progenitors in mouse preBötzinger complex
Kottick A, Martin C, Del Negro C
Physiol Rep
. 2017 Jun;
5(11).
PMID: 28611151
The brainstem preBötzinger complex (preBötC) generates the inspiratory breathing rhythm, and its core rhythmogenic interneurons are derived from Dbx1-expressing progenitors. To study the neural bases of breathing, tamoxifen-inducible Cre-driver mice...
17.
Vann N, Pham F, Hayes J, Kottick A, Del Negro C
PLoS One
. 2016 Sep;
11(9):e0162418.
PMID: 27611210
Interneurons derived from Dbx1-expressing precursors located in the brainstem preBötzinger complex (preBötC) putatively form the core oscillator for inspiratory breathing movements. We tested this Dbx1 core hypothesis by expressing archaerhodopsin...
18.
Song H, Hayes J, Vann N, Wang X, LaMar M, Del Negro C
J Neurosci
. 2016 Jul;
36(27):7223-33.
PMID: 27383596
Unlabelled: Breathing in mammals depends on rhythms that originate from the preBötzinger complex (preBötC) of the ventral medulla and a network of brainstem and spinal premotor neurons. The rhythm-generating core...
19.
Revill A, Vann N, Akins V, Kottick A, Gray P, Del Negro C, et al.
Elife
. 2015 Dec;
4.
PMID: 26687006
All behaviors require coordinated activation of motoneurons from central command and premotor networks. The genetic identities of premotoneurons providing behaviorally relevant excitation to any pool of respiratory motoneurons remain unknown....
20.
Phillips W, Herly M, Del Negro C, Rekling J
J Neurophysiol
. 2015 Dec;
115(2):1063-70.
PMID: 26655824
Study of acute brain stem slice preparations in vitro has advanced our understanding of the cellular and synaptic mechanisms of respiratory rhythm generation, but their inherent limitations preclude long-term manipulation...