Christopher A Del Negro
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Explore the profile of Christopher A Del Negro including associated specialties, affiliations and a list of published articles.
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53
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Recent Articles
1.
Gu J, Sugimura Y, Kato F, Del Negro C
Eur J Neurosci
. 2024 Nov;
60(11):6799-6811.
PMID: 39498665
Breathing behaviour is subject to emotional regulation, but the underlying mechanisms remain unclear. Here, we demonstrate a direct relationship between the central amygdala, a major output hub of the limbic...
2.
Borrus D, Stettler M, Grover C, Kalajian E, Gu J, Conradi Smith G, et al.
J Physiol
. 2024 Feb;
602(5):809-834.
PMID: 38353596
Breathing behaviour involves the generation of normal breaths (eupnoea) on a timescale of seconds and sigh breaths on the order of minutes. Both rhythms emerge in tandem from a single...
3.
da Silva Jr C, Grover C, Picardo M, Del Negro C
Cell Rep
. 2023 Aug;
42(8):113000.
PMID: 37590134
Inspiration is the inexorable active phase of breathing. The brainstem pre-Bötzinger complex (preBötC) gives rise to inspiratory neural rhythm, but its underlying cellular and ionic bases remain unclear. The long-standing...
4.
David C, Sugimura Y, Kallurkar P, Picardo M, Saha M, Conradi Smith G, et al.
Sci Data
. 2022 Jul;
9(1):457.
PMID: 35907922
Neurons in the brainstem preBötzinger complex (preBötC) generate the rhythm and rudimentary motor pattern for inspiratory breathing movements. We performed whole-cell patch-clamp recordings from inspiratory neurons in the preBötC of...
5.
Ashhad S, Kam K, Del Negro C, Feldman J
Annu Rev Neurosci
. 2022 Mar;
45:223-247.
PMID: 35259917
Breathing is a vital rhythmic motor behavior with a surprisingly broad influence on the brain and body. The apparent simplicity of breathing belies a complex neural control system, the breathing...
6.
Kallurkar P, Picardo M, Sugimura Y, Saha M, Conradi Smith G, Del Negro C
Sci Rep
. 2022 Feb;
12(1):2923.
PMID: 35190626
Breathing depends on interneurons in the preBötzinger complex (preBötC) derived from Dbx1-expressing precursors. Here we investigate whether rhythm- and pattern-generating functions reside in discrete classes of Dbx1 preBötC neurons. In...
7.
Revill A, Katzell A, Del Negro C, Milsom W, Funk G
Front Physiol
. 2021 Apr;
12:626470.
PMID: 33927636
The pre-Bötzinger complex (preBötC) of the ventral medulla generates the mammalian inspiratory breathing rhythm. When isolated in explants and deprived of synaptic inhibition, the preBötC continues to generate inspiratory-related rhythm....
8.
Borrus D, Grover C, Conradi Smith G, Del Negro C
eNeuro
. 2020 May;
7(3).
PMID: 32393585
The preBötzinger complex (preBötC) gives rise to two types of breathing behavior under normal physiological conditions: eupnea and sighing. Here, we examine the neural mechanisms that couple their underlying rhythms....
9.
Kallurkar P, Grover C, Picardo M, Del Negro C
eNeuro
. 2020 Jan;
7(1).
PMID: 31888961
The preBötzinger complex (preBötC) generates the rhythm and rudimentary motor pattern for inspiratory breathing movements. Here, we test "burstlet" theory (Kam et al., 2013a), which posits that low amplitude burstlets,...
10.
Picardo M, Sugimura Y, Dorst K, Kallurkar P, Akins V, Ma X, et al.
PLoS Biol
. 2019 Feb;
17(2):e2006094.
PMID: 30789900
Inspiratory breathing movements depend on pre-Bötzinger complex (preBötC) interneurons that express calcium (Ca2+)-activated nonselective cationic current (ICAN) to generate robust neural bursts. Hypothesized to be rhythmogenic, reducing ICAN is predicted...