Christophe Plisson
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Explore the profile of Christophe Plisson including associated specialties, affiliations and a list of published articles.
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41
Citations
647
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Recent Articles
11.
Haywood T, Cesarec S, Kealey S, Plisson C, Miller P
Medchemcomm
. 2018 Aug;
9(8):1311-1314.
PMID: 30151085
Herein we report the preparation of ammonium [C]thiocyanate the reaction of [C]CS with ammonia. The [C]SCN ion is demonstrated as a potent nucleophile that can be used to readily generate...
12.
Boscutti G, Rabiner E, Plisson C
Neurosci Lett
. 2018 Aug;
691:11-17.
PMID: 30099081
The development of β emitter tracers labelled with carbon-11 or fluorine-18 having optimal characteristics of affinity and selectivity for the phosphodiesterase 10 A protein has received considerable attention, due to...
13.
Brown N, Williams M, Arkenau H, Fleming R, Tolson J, Yan L, et al.
Neuro Oncol
. 2018 May;
20(12):1634-1642.
PMID: 29788497
Background: GSK2256098 is a novel oral focal adhesion kinase (FAK) inhibitor. Preclinical studies demonstrate growth inhibition in glioblastoma cell lines. However, rodent studies indicate limited blood-brain barrier (BBB) penetration. In...
14.
Marzano C, Jakobsen S, Salinas C, Tang S, Bender D, Passchier J, et al.
J Labelled Comp Radiopharm
. 2017 Jul;
60(12):556-565.
PMID: 28670707
Oxytocin is known to be implicated in a variety of functions, such as learning, stress, anxiety, feeding, and pain perception. Oxytocin is also important for social memory and attachment, human...
15.
Mirzaei N, Tang S, Ashworth S, Coello C, Plisson C, Passchier J, et al.
Glia
. 2016 Mar;
64(6):993-1006.
PMID: 26959396
Microglial activation has been linked with deficits in neuronal function and synaptic plasticity in Alzheimer's disease (AD). The mitochondrial translocator protein (TSPO) is known to be upregulated in reactive microglia....
16.
Haywood T, Kealey S, Sanchez-Cabezas S, Hall J, Allott L, Smith G, et al.
Chemistry
. 2015 May;
21(25):9034-8.
PMID: 25965348
Herein a new (11) C radiolabelling strategy for the fast and efficient synthesis of thioureas and related derivatives using the novel synthon, (11) CS2 , is reported. This approach has...
17.
Lin S, Labaree D, Chen M, Holden D, Gallezot J, Kapinos M, et al.
Synapse
. 2014 Dec;
69(2):86-95.
PMID: 25450608
[(11)C]MP-10 is a potent and specific PET tracer previously shown to be suitable for imaging the phosphodiesterase 10A (PDE10A) in baboons with reversible kinetics and high specific binding. However, another...
18.
Saleem A, Murphy P, Plisson C, Lahn M
ScientificWorldJournal
. 2014 Sep;
2014:269605.
PMID: 25202719
In early drug development advanced imaging techniques can help with progressing new molecular entities (NME) to subsequent phases of drug development and thus reduce attrition. However, several organizational, operational, and...
19.
Haslop A, Wells L, Gee A, Plisson C, Long N
Mol Pharm
. 2014 Aug;
11(11):3818-22.
PMID: 25158244
(18)F labeled phosphonium salts are increasingly important molecular probes for targeting the mitochondrial membrane potential depletion during apoptosis and for detecting myocardial perfusion deficit. Here, we introduce three new tracers,...
20.
Plisson C, Weinzimmer D, Jakobsen S, Natesan S, Salinas C, Lin S, et al.
J Nucl Med
. 2014 Mar;
55(4):595-601.
PMID: 24614221
Unlabelled: Four novel phosphodiesterase 10A (PDE10A) PET tracers have been synthesized, characterized in preclinical studies, and compared with the previously reported (11)C-MP-10. Methods: On the basis of in vitro data,...