Christophe Ginestier
Overview
Explore the profile of Christophe Ginestier including associated specialties, affiliations and a list of published articles.
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Articles
99
Citations
8587
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Recent Articles
1.
Rouault C, Bansard L, Martinez-Balsalobre E, Bonnet C, Wicinski J, Lin S, et al.
Nat Commun
. 2025 Mar;
16(1):2159.
PMID: 40038300
The targeting of cancer stem cells (CSCs) has proven to be an effective approach for limiting tumor progression, thus necessitating the identification of new drugs with anti-CSC activity. Through a...
2.
Rodriguez R, Caneque T, Baron L, Muller S, Carmona A, Colombeau L, et al.
Res Sq
. 2024 Apr;
PMID: 38659936
Iron catalyses the oxidation of lipids in biological membranes and promotes a form of cell death referred to as ferroptosis. Identifying where this chemistry takes place in the cell can...
3.
Laisne M, Rodgers B, Benlamara S, Wicinski J, Nicolas A, Djerroudi L, et al.
Oncogene
. 2024 Mar;
43(18):1369-1385.
PMID: 38467851
Breast cancer is the most prevalent type of cancer in women worldwide. Within breast tumors, the basal-like subtype has the worst prognosis, prompting the need for new tools to understand,...
4.
Serrano A, Weber T, Berthelet J, El-Saafin F, Gadipally S, Charafe-Jauffret E, et al.
Commun Biol
. 2023 Aug;
6(1):821.
PMID: 37550477
Intratumoural heterogeneity is associated with poor outcomes in breast cancer. To understand how malignant clones survive and grow in metastatic niches, in vivo models using cell lines and patient-derived xenografts...
5.
Puppo M, Valluru M, Croset M, Ceresa D, Iuliani M, Khan A, et al.
Br J Cancer
. 2023 Jul;
129(5):754-771.
PMID: 37443350
Background: Breast cancer (BC) metastasis, which often occurs in bone, contributes substantially to mortality. MicroRNAs play a fundamental role in BC metastasis, although microRNA-regulated mechanisms driving metastasis progression remain poorly...
6.
Lin S, Margueron R, Charafe-Jauffret E, Ginestier C
Trends Cell Biol
. 2023 Apr;
33(10):887-897.
PMID: 37061355
Increase in lineage infidelity and/or imbalance is frequently observed around the earliest stage of breast tumor initiation. In response to disruption of homeostasis, differentiated cells can partially lose their identity...
7.
Pastor S, Wicinski J, Charafe-Jauffret E, Verhoeyen E, Guittard G, Ginestier C
STAR Protoc
. 2023 Feb;
4(1):102055.
PMID: 36853718
Primary human mammary epithelial cells (pHMECs) are known to be remarkably difficult to engineer genetically. Here, we present a protocol for efficient transduction of pHMECs using a baboon retroviral envelope...
8.
Pinna G, Vandamme M, Rouault C, Charafe-Jauffret E, Ginestier C
Methods Cell Biol
. 2022 Jul;
170:81-99.
PMID: 35811105
Tumor heterogeneity represents a major hurdle for therapy. This cellular heterogeneity is mainly sustained by different subpopulations of tumorigenic cells, the so-called cancer stem cells (CSCs). CSCs burden is associated...
9.
Berthelet J, Foroutan M, Bhuva D, Whitfield H, El-Saafin F, Cursons J, et al.
Cancers (Basel)
. 2022 May;
14(10).
PMID: 35626009
The development of therapies that target specific disease subtypes has dramatically improved outcomes for patients with breast cancer. However, survival gains have not been uniform across patients, even within a...
10.
Richart L, Picod-Chedotel M, Wassef M, Macario M, Aflaki S, Salvador M, et al.
Cell
. 2022 May;
185(12):2164-2183.e25.
PMID: 35597241
X inactivation (XCI) is triggered by upregulation of XIST, which coats the chromosome in cis, promoting formation of a heterochromatic domain (Xi). XIST role beyond initiation of XCI is only...