Christophe F Grosset
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Explore the profile of Christophe F Grosset including associated specialties, affiliations and a list of published articles.
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24
Citations
308
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Recent Articles
1.
Sanceau J, Poupel L, Joubel C, Lagoutte I, Caruso S, Pinto S, et al.
Mol Ther
. 2024 Feb;
32(4):1125-1143.
PMID: 38311851
The CTNNB1 gene, encoding β-catenin, is frequently mutated in hepatocellular carcinoma (HCC, ∼30%) and in hepatoblastoma (HB, >80%), in which DLK1/DIO3 locus induction is correlated with CTNNB1 mutations. Here, we...
2.
Shreya S, Grosset C, Jain B
Int J Mol Sci
. 2023 Sep;
24(18).
PMID: 37762367
Endoplasmic reticulum (ER) is the site for synthesis and folding of secreted and transmembrane proteins. Disturbance in the functioning of ER leads to the accumulation of unfolded and misfolded proteins,...
3.
Gest C, Sena S, Dif L, Neaud V, Loesch R, Dugot-Senant N, et al.
JHEP Rep
. 2023 May;
5(5):100691.
PMID: 37153687
Background & Aims: β-catenin is a well-known effector of the Wnt pathway, and a key player in cadherin-mediated cell adhesion. Oncogenic mutations of β-catenin are very frequent in paediatric liver...
4.
Alannan M, Trezeguet V, Dias Amoedo N, Rossignol R, Mahfouf W, Rezvani H, et al.
Cancers (Basel)
. 2023 Jan;
15(1).
PMID: 36612001
Alterations in lipid handling are an important hallmark in cancer. Our aim here is to target key metabolic enzymes to reshape the oncogenic lipid metabolism triggering irreversible cell breakdown. We...
5.
Alannan M, Fatrouni H, Trezeguet V, Dittrich-Domergue F, Moreau P, Siegfried G, et al.
Cells
. 2023 Jan;
12(1).
PMID: 36611859
Deregulated lipid metabolism is a common feature of liver cancers needed to sustain tumor cell growth and survival. We aim at taking advantage of this vulnerability and rewiring the oncogenic...
6.
Dong Y, Alonso F, Jahjah T, Fremaux I, Grosset C, Genot E
Cell Mol Life Sci
. 2022 Mar;
79(4):208.
PMID: 35347477
Angiogenesis involves cell specification orchestrated by regulatory interactions between the vascular endothelial growth factor and Notch signaling pathways. However, the role of microRNAs in these regulations remains poorly explored. Here...
7.
Rahal F, Capdevielle C, Rousseau B, Izotte J, Dupuy J, Cappellen D, et al.
Neurooncol Adv
. 2022 Mar;
4(1):vdac018.
PMID: 35300150
Background: Diffuse Midline Glioma, H3K27M-mutant (DMG) is a rare, highly aggressive pediatric tumor affecting the brainstem, and is one of the deadliest cancers. Currently available treatment options such as chemotherapy...
8.
Denis de Senneville B, Khoubai F, Bevilacqua M, Labedade A, Flosseau K, Chardot C, et al.
Commun Biol
. 2021 Dec;
4(1):1390.
PMID: 34903822
Despite recent progress in the characterization of tumour components, the tri-dimensional (3D) organization of this pathological tissue and the parameters determining its internal architecture remain elusive. Here, we analysed the...
9.
Khoubai F, Grosset C
Int J Mol Sci
. 2021 Nov;
22(21).
PMID: 34768967
Mitogen-activated protein kinases (MAPKs) are essential for proper cell functioning as they regulate many molecular effectors. Careful regulation of MAPKs is therefore required to avoid MAPK pathway dysfunctions and pathologies....
10.
Trezeguet V, Lesjean S, Veschambre P, Auguste P, Turcq B, Ducassou S, et al.
Bull Cancer
. 2020 Oct;
107(12):1284-1287.
PMID: 33097208
No abstract available.