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Christine Toulas

Explore the profile of Christine Toulas including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 51
Citations 979
Followers 0
Related Specialties
Oncology
Biochemistry
Molecular Biology
Top 10 Co-Authors
Caroline Delmas
Gilles Favre
Elizabeth Cohen-Jonathan Moyal
Elizabeth Cohen-Jonathan-Moyal
Anthony Lemarie
Dominique Stoppa-Lyonnet
Nancy Uhrhammer
Nicolas Skuli
Julia Gilhodes
Sylvie Monferran
Published In
Int J Cancer
Oncotarget
Eur J Cancer
Cancers (Basel)
Oncogene
Affiliations
Soon will be listed here.
Recent Articles
1.
The STEMRI trial: Magnetic resonance spectroscopy imaging can define tumor areas enriched in glioblastoma stem-like cells
Lemarie A, Lubrano V, Delmas C, Lusque A, Cerapio J, Perrier M, et al.
Sci Adv . 2023 Nov; 9(44):eadi0114. PMID: 37922359
Despite maximally safe resection of the magnetic resonance imaging (MRI)-defined contrast-enhanced (CE) central tumor area and chemoradiotherapy, most patients with glioblastoma (GBM) relapse within a year in peritumoral FLAIR regions....
2.
Multigene Panel Sequencing Identifies a Novel Germline Mutation Profile in Male Breast Cancer Patients
Al Saati A, Vande Perre P, Plenecassagnes J, Gilhodes J, Monselet N, Cabarrou B, et al.
Int J Mol Sci . 2023 Sep; 24(18). PMID: 37762649
Even though male breast cancer (MBC) risk encompasses both genetic and environmental aetiologies, the primary risk factor is a germline pathogenic variant (PV) or likely pathogenic variant (LPV) in and/or...
3.
Association and performance of polygenic risk scores for breast cancer among French women presenting or not a familial predisposition to the disease
Jiao Y, Truong T, Eon-Marchais S, Mebirouk N, Caputo S, Dondon M, et al.
Eur J Cancer . 2022 Dec; 179:76-86. PMID: 36509001
Background: Three partially overlapping breast cancer polygenic risk scores (PRS) comprising 77, 179 and 313 SNPs have been proposed for European-ancestry women by the Breast Cancer Association Consortium (BCAC) for...
4.
Classification of 101 BRCA1 and BRCA2 variants of uncertain significance by cosegregation study: A powerful approach
Caputo S, Golmard L, Leone M, Damiola F, Guillaud-Bataille M, Revillion F, et al.
Am J Hum Genet . 2021 Oct; 108(10):1907-1923. PMID: 34597585
Up to 80% of BRCA1 and BRCA2 genetic variants remain of uncertain clinical significance (VUSs). Only variants classified as pathogenic or likely pathogenic can guide breast and ovarian cancer prevention...
5.
An unusual phenotype occurs in 15% of mismatch repair-deficient tumors and is associated with non-colorectal cancers and genetic syndromes
Jaffrelot M, Fares N, Brunac A, Laurenty A, Danjoux M, Grand D, et al.
Mod Pathol . 2021 Sep; 35(3):427-437. PMID: 34545179
Immunohistochemistry (IHC) and/or MSI-PCR (microsatellite instability-polymerase chain reaction) tests are performed routinely to detect mismatch repair deficiency (MMR-D). Classical MMR-D tumors present a loss of MLH1/PMS2 or MSH2/MSH6 with MSI-High....
6.
TUMOSPEC: A Nation-Wide Study of Hereditary Breast and Ovarian Cancer Families with a Predicted Pathogenic Variant Identified through Multigene Panel Testing
Lesueur F, Eon-Marchais S, Bonnet-Boissinot S, Beauvallet J, Dondon M, Golmard L, et al.
Cancers (Basel) . 2021 Aug; 13(15). PMID: 34359559
Assessment of age-dependent cancer risk for carriers of a predicted pathogenic variant (PPV) is often hampered by biases in data collection, with a frequent under-representation of cancer-free PPV carriers. TUMOSPEC...
7.
Translation reprogramming by eIF3 linked to glioblastoma resistance
Bertorello J, Sesen J, Gilhodes J, Evrard S, Courtade-Saidi M, Augustus M, et al.
NAR Cancer . 2021 Jul; 2(3):zcaa020. PMID: 34316689
Intrinsic resistance to current therapies, leading to dismal clinical outcomes, is a hallmark of glioblastoma multiforme (GBM), the most common and aggressive brain tumor. Understanding the underlying mechanisms of such...
8.
5' Region Large Genomic Rearrangements in the Gene in French Families: Identification of a Tandem Triplication and Nine Distinct Deletions with Five Recurrent Breakpoints
Caputo S, Telly D, Briaux A, Sesen J, Ceppi M, Bonnet F, et al.
Cancers (Basel) . 2021 Jul; 13(13). PMID: 34202044
Background: Large genomic rearrangements (LGR) in consisting of deletions/duplications of one or several exons have been found throughout the gene with a large proportion occurring in the 5' region from...
9.
Further delineation of the NTHL1 associated syndrome: A report from the French Oncogenetic Consortium
Boulouard F, Kasper E, Buisine M, Lienard G, Vasseur S, Manase S, et al.
Clin Genet . 2021 Jan; 99(5):662-672. PMID: 33454955
Biallelic pathogenic variants in the NTHL1 (Nth like DNA glycosylase 1) gene cause a recently identified autosomal recessive hereditary cancer syndrome predisposing to adenomatous polyposis and colorectal cancer. Half of...
10.
The m6A RNA Demethylase ALKBH5 Promotes Radioresistance and Invasion Capability of Glioma Stem Cells
Kowalski-Chauvel A, Lacore M, Arnauduc F, Delmas C, Toulas C, Cohen-Jonathan-Moyal E, et al.
Cancers (Basel) . 2020 Dec; 13(1). PMID: 33375621
Recurrence of GBM is thought to be due to GBMSCs, which are particularly chemo-radioresistant and characterized by a high capacity to invade normal brain. Evidence is emerging that modulation of...