Christine Podrini
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Explore the profile of Christine Podrini including associated specialties, affiliations and a list of published articles.
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19
Citations
892
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Recent Articles
11.
Podrini C, Koffas A, Chokshi S, Vinciguerra M, Lelliott C, White J, et al.
FASEB J
. 2014 Dec;
29(5):1676-87.
PMID: 25526730
The importance of epigenetic changes in the development of hepatic steatosis is largely unknown. The histone variant macroH2A1 under alternative splicing gives rise to macroH2A1.1 and macroH2A1.2. In this study,...
12.
Bentley L, Esapa C, Nesbit M, Head R, Evans H, Lath D, et al.
Endocrinology
. 2013 Dec;
155(3):908-22.
PMID: 24302625
Cushing's syndrome, which is characterized by excessive circulating glucocorticoid concentrations, may be due to ACTH-dependent or -independent causes that include anterior pituitary and adrenal cortical tumors, respectively. ACTH secretion is...
13.
White J, Gerdin A, Karp N, Ryder E, Buljan M, Bussell J, et al.
Cell
. 2013 Jul;
154(2):452-64.
PMID: 23870131
Mutations in whole organisms are powerful ways of interrogating gene function in a realistic context. We describe a program, the Sanger Institute Mouse Genetics Project, that provides a step toward...
14.
Podrini C, Cambridge E, Lelliott C, Carragher D, Estabel J, Gerdin A, et al.
Mamm Genome
. 2013 May;
24(5-6):240-51.
PMID: 23712496
C57BL/6N (B6N) is becoming the standard background for genetic manipulation of the mouse genome. The B6N, whose genome is very closely related to the reference C57BL/6J genome, is versatile in...
15.
Rappa F, Greco A, Podrini C, Cappello F, Foti M, Bourgoin L, et al.
PLoS One
. 2013 Feb;
8(1):e54458.
PMID: 23372727
Background: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Prevention and risk reduction are important and the identification of specific biomarkers for early diagnosis of HCC represents...
16.
Basel-Vanagaite L, Dallapiccola B, Ramirez-Solis R, Segref A, Thiele H, Edwards A, et al.
Am J Hum Genet
. 2012 Dec;
91(6):998-1010.
PMID: 23200864
Ubiquitination plays a crucial role in neurodevelopment as exemplified by Angelman syndrome, which is caused by genetic alterations of the ubiquitin ligase-encoding UBE3A gene. Although the function of UBE3A has...
17.
Bosman E, Estabel J, Ismail O, Podrini C, White J, Steel K
Mamm Genome
. 2012 Nov;
24(1-2):44-53.
PMID: 23160729
Large-scale N-ethyl-N-nitrosourea (ENU) mutagenesis has provided many rodent models for human disease. Here we describe the initial characterization and mapping of a recessive mutation that leads to degeneration of the...
18.
Podrini C, Borghesan M, Greco A, Pazienza V, Mazzoccoli G, Vinciguerra M
Curr Pharm Des
. 2012 Oct;
19(15):2737-46.
PMID: 23092327
Non-alcoholic fatty liver disease (NAFLD), an accumulation of intra-hepatic triglycerides that is often considered the hepatic manifestation of insulin resistance, is the most common cause of chronic liver disease in...
19.
Nijnik A, Clare S, Hale C, Raisen C, McIntyre R, Yusa K, et al.
Blood
. 2011 Dec;
119(6):1370-9.
PMID: 22184403
Stem cell differentiation and lineage specification depend on coordinated programs of gene expression, but our knowledge of the chromatin-modifying factors regulating these events remains incomplete. Ubiquitination of histone H2A (H2A-K119u)...