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» Authors » Christine H Rumpf

Christine H Rumpf

Explore the profile of Christine H Rumpf including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 5
Citations 164
Followers 0
Related Specialties
Molecular Biology
Microbiology
Biotechnology
Top 10 Co-Authors
Daniel L Minor Jr
Felix Findeisen
Filip Van Petegem
Barbara C Kahl
Susanne Deiwick
Timo Janssen
Robert Jonathan Hait
Elizabeth S Cooley
Eun Young Kim
Bianca Schwartbeck
Published In
Structure
ACS Chem Neurosci
EMBO J
Microbes Infect
J Mol Biol
Affiliations
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Recent Articles
1.
Mucoid - Prevalence and Association with Lung Function in People with Cystic Fibrosis
Rumpf C, Janssen T, Hait R, Romme K, Decker C, Peters J, et al.
Am J Respir Crit Care Med . 2025 Feb; PMID: 39918841
Rationale: The mucoid phenotype of is caused by adaptation. Excessive biofilm formation associated with a protective effect for mucoid was observed in isolates from respiratory samples of people with cystic...
2.
Various mutations in icaR, the repressor of the icaADBC locus, occur in mucoid Staphylococcus aureus isolates recovered from the airways of people with cystic fibrosis
Schwartbeck B, Rumpf C, Hait R, Janssen T, Deiwick S, Schwierzeck V, et al.
Microbes Infect . 2024 Feb; 26(4):105306. PMID: 38316375
Staphylococcus aureus is one of the major pathogens isolated from the airways of people with cystic fibrosis (pwCF). Recently, we described a mucoid S. aureus phenotype from respiratory specimens of...
3.
Stapled Voltage-Gated Calcium Channel (Ca) α-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of Ca Function
Findeisen F, Campiglio M, Jo H, Abderemane-Ali F, Rumpf C, Pope L, et al.
ACS Chem Neurosci . 2017 Mar; 8(6):1313-1326. PMID: 28278376
For many voltage-gated ion channels (VGICs), creation of a properly functioning ion channel requires the formation of specific protein-protein interactions between the transmembrane pore-forming subunits and cystoplasmic accessory subunits. Despite...
4.
Apo states of calmodulin and CaBP1 control CaV1 voltage-gated calcium channel function through direct competition for the IQ domain
Findeisen F, Rumpf C, Minor Jr D
J Mol Biol . 2013 Jul; 425(17):3217-34. PMID: 23811053
In neurons, binding of calmodulin (CaM) or calcium-binding protein 1 (CaBP1) to the CaV1 (L-type) voltage-gated calcium channel IQ domain endows the channel with diametrically opposed properties. CaM causes calcium-dependent...
5.
Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization
Kim E, Rumpf C, Van Petegem F, Arant R, Findeisen F, Cooley E, et al.
EMBO J . 2010 Oct; 29(23):3924-38. PMID: 20953164
Interactions between voltage-gated calcium channels (Ca(V)s) and calmodulin (CaM) modulate Ca(V) function. In this study, we report the structure of a Ca(2+)/CaM Ca(V)1.2 C-terminal tail complex that contains two PreIQ...
6.
Structures of CaV2 Ca2+/CaM-IQ domain complexes reveal binding modes that underlie calcium-dependent inactivation and facilitation
Kim E, Rumpf C, Fujiwara Y, Cooley E, Van Petegem F, Minor Jr D
Structure . 2008 Oct; 16(10):1455-67. PMID: 18940602
Calcium influx drives two opposing voltage-activated calcium channel (Ca(V)) self-modulatory processes: calcium-dependent inactivation (CDI) and calcium-dependent facilitation (CDF). Specific Ca(2+)/calmodulin (Ca(2+)/CaM) lobes produce CDI and CDF through interactions with the...