Christina Minnick
Overview
Explore the profile of Christina Minnick including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
59
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0
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Recent Articles
1.
Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections
Loughran H, Schirripa K, Roecker A, Breslin M, Tong L, Fillgrove K, et al.
ACS Med Chem Lett
. 2024 Jan;
15(1):123-131.
PMID: 38229758
Inhibition of glucosylceramide synthase (GCS) has been proposed as a therapeutic strategy for the treatment of Parkinson's Disease (PD), particularly in patients where glycosphingolipid accumulation and lysosomal impairment are thought...
2.
Roecker A, Schirripa K, Loughran H, Tong L, Liang T, Fillgrove K, et al.
ACS Med Chem Lett
. 2023 Feb;
14(2):146-155.
PMID: 36793422
Parkinson's disease is the second most prevalent progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra. Loss-of-function mutations in GBA, the gene that encodes for...
3.
Cosden M, Jinn S, Yao L, Gretzula C, Kandebo M, Toolan D, et al.
Neurobiol Dis
. 2021 Sep;
159:105507.
PMID: 34509608
Mutations in the lysosomal enzyme glucocerebrosidase (GCase, GBA1 gene) are the most common genetic risk factor for developing Parkinson's disease (PD). GCase metabolizes the glycosphingolipids glucosylceramide (GlcCer) and glucosylsphingosine (GlcSph)....
4.
Hong C, Byrne N, Zamlynny B, Tummala S, Xiao L, Shipman J, et al.
Nat Commun
. 2021 Feb;
12(1):815.
PMID: 33547286
Narcolepsy type 1 (NT1) is a chronic neurological disorder that impairs the brain's ability to control sleep-wake cycles. Current therapies are limited to the management of symptoms with modest effectiveness...