Christina Lutz-Nicoladoni
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Explore the profile of Christina Lutz-Nicoladoni including associated specialties, affiliations and a list of published articles.
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13
Citations
331
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Recent Articles
1.
Lutz-Nicoladoni C, Thuille N, Wachowicz K, Gruber T, Leitges M, Baier G
Immunol Lett
. 2017 Sep;
160(1):104.
PMID: 28859835
No abstract available.
2.
Lutz-Nicoladoni C, Wolf D, Sopper S
Front Oncol
. 2015 Mar;
5:58.
PMID: 25815272
Maintenance of immunological tolerance is a critical hallmark of the immune system. Several signaling checkpoints necessary to balance activating and inhibitory input to immune cells have been described so far,...
3.
Wallner S, Lutz-Nicoladoni C, Tripp C, Gastl G, Baier G, Penninger J, et al.
PLoS One
. 2013 Jun;
8(6):e65178.
PMID: 23762309
Dendritic cells (DCs) are potent antigen-presenting cells with a promising potential in cancer immunotherapy. Cbl proteins are E3 ubiquitin ligases and have been implicated in regulating the functional activity of...
4.
Lutz-Nicoladoni C, Christina L, Thuille N, Nikolaus T, Wachowicz K, Katarzyna W, et al.
Immunol Lett
. 2013 Feb;
151(1-2):31-8.
PMID: 23439007
The physiological functions of PKCα and PKCθ isotypes downstream of the antigen receptor have been defined in CD3(+) T cells. In contrast, no function of the second conventional PKC member,...
5.
Thuille N, Wachowicz K, Hermann-Kleiter N, Kaminski S, Fresser F, Lutz-Nicoladoni C, et al.
PLoS One
. 2013 Jan;
8(1):e53709.
PMID: 23335970
In T cells PKCθ mediates the activation of critical signals downstream of TCR/CD28 stimulation. We investigated the molecular mechanisms by which PKCθ regulates NFκB transactivation by examining PKCθ/β single and...
6.
Hinterleitner R, Gruber T, Pfeifhofer-Obermair C, Lutz-Nicoladoni C, Tzankov A, Schuster M, et al.
PLoS One
. 2012 Sep;
7(9):e44295.
PMID: 22962608
The ubiquitin ligase Cbl-b is an established regulator of T cell immune response thresholds. We recently showed that adoptive cell transfer (ACT) of cblb(-/-) CD8(+) T cells enhances dendritic cell...
7.
Lutz-Nicoladoni C, Wallner S, Stoitzner P, Pircher M, Gruber T, Wolf A, et al.
Immunol Cell Biol
. 2011 Mar;
90(1):130-4.
PMID: 21383769
The success of cancer immunotherapy is limited by potent endogenous immune-evasion mechanisms, which are at least in part mediated by transforming growth factor-β (TGF-β). The E3 ubiquitin ligase Cbl-b is...
8.
Thuille N, Lutz-Nicoladoni C, Letschka T, Hermann-Kleiter N, Heit I, Baier G
Immunol Lett
. 2009 Aug;
126(1-2):54-9.
PMID: 19682494
PKCtheta serine/threonine and Itk tyrosine protein kinases have been implicated in T lymphocyte signal transmission. We observed a PKCtheta/Itk complex after T cell activation, raising the possibility that PKCtheta and...
9.
Evenou J, Wagner J, Zenke G, Brinkmann V, Wagner K, Kovarik J, et al.
J Pharmacol Exp Ther
. 2009 Jun;
330(3):792-801.
PMID: 19491325
There is a pressing need for immunosuppressants with an improved safety profile. The search for novel approaches to blocking T-cell activation led to the development of the selective protein kinase...
10.
Gruber T, Hermann-Kleiter N, Pfeifhofer-Obermair C, Lutz-Nicoladoni C, Thuille N, Letschka T, et al.
Mol Immunol
. 2009 Apr;
46(10):2071-9.
PMID: 19356803
The physiological roles of PKC alpha and PKC theta were defined in T cell immune functions downstream of the antigen receptor. To investigate the hypothesis that both PKC isotypes may...