Christian Sinzger
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Explore the profile of Christian Sinzger including associated specialties, affiliations and a list of published articles.
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71
Citations
2398
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Recent Articles
1.
Zehner M, Alt M, Ashurov A, Goldsmith J, Spies R, Weiler N, et al.
Immunity
. 2023 Nov;
56(11):2602-2620.e10.
PMID: 37967532
Human cytomegalovirus (HCMV) can cause severe diseases in fetuses, newborns, and immunocompromised individuals. Currently, no vaccines are approved, and treatment options are limited. Here, we analyzed the human B cell...
2.
Weiler N, Laib Sampaio K, Scherer M, Sinzger C
Biotechniques
. 2023 Oct;
75(5):183-194.
PMID: 37846844
Working with recent isolates of human cytomegalovirus (HCMV) is complicated by their strictly cell-associated growth with lack of infectivity in the supernatant. Adaptation to cell-free growth is associated with disruption...
3.
Characterization of Plasma Immunoglobulin G Responses in Elite Neutralizers of Human Cytomegalovirus
Harnois M, Dennis M, Stohr D, Valencia S, Rodgers N, Semmes E, et al.
J Infect Dis
. 2022 Aug;
226(9):1667-1677.
PMID: 35970817
Background: Human cytomegalovirus (HCMV) is the most common infectious complication of organ transplantation and cause of birth defects worldwide. There are limited therapeutic options and no licensed vaccine to prevent...
4.
Braun B, Laib Sampaio K, Kuderna A, Widmann M, Sinzger C
Viruses
. 2022 Jul;
14(7).
PMID: 35891541
Polymorphonuclear leukocytes (PMNs) presumably transmit human cytomegalovirus (HCMV) between endothelial cells in blood vessels and thereby facilitate spread to peripheral organs. We aimed to identify viral components that contribute to...
5.
Weiler N, Laib Sampaio K, Stanton R, Sinzger C
J Virol Methods
. 2022 May;
305:114537.
PMID: 35526667
Due to strictly cell-associated growth, experiments requiring cell-free virus are not applicable to recent clinical HCMV isolates to date. On the other hand, adaptation to cell-free growth is associated with...
6.
Braun B, Fischer D, Laib Sampaio K, Mezger M, Stohr D, Stanton R, et al.
Viruses
. 2021 Sep;
13(9).
PMID: 34578361
Cell-free human cytomegalovirus (HCMV) can be inhibited by a soluble form of the cellular HCMV-receptor PDGFRα, resembling neutralization by antibodies. The cell-associated growth of recent HCMV isolates, however, is resistant...
7.
Laib Sampaio K, Lutz C, Engels R, Stohr D, Sinzger C
Viruses
. 2021 Jul;
13(6).
PMID: 34201364
The human cytomegalovirus (HCMV) infects fibroblasts via an interaction of its envelope glycoprotein gO with the cellular platelet-derived growth factor receptor alpha (PDGFRα), and soluble derivatives of this receptor can...
8.
Braun B, Sinzger C
Med Microbiol Immunol
. 2021 Jun;
210(4):197-209.
PMID: 34091753
Polymorphonuclear leukocytes (PMNs) are regarded as vehicles for the hematogenous dissemination of human cytomegalovirus (HCMV). In cell culture, this concept has been validated with cell-free laboratory strains but not yet...
9.
Weiler N, Paal C, Adams K, Calcaterra C, Fischer D, Stanton R, et al.
Viruses
. 2021 Apr;
13(4).
PMID: 33918406
The role of viral envelope glycoproteins, particularly the accessory proteins of trimeric and pentameric gH/gL-complexes, in cell-associated spread of human cytomegalovirus (HCMV) is unclear. We aimed to investigate their contribution...
10.
Feldmann S, Grimm I, Stohr D, Antonini C, Lischka P, Sinzger C, et al.
PLoS Pathog
. 2021 Mar;
17(3):e1009471.
PMID: 33780515
Platelet-derived growth factor receptor alpha (PDGFRα) serves as an entry receptor for the human cytomegalovirus (HCMV), and soluble PDGFRα-Fc can neutralize HCMV at a half-maximal effective concentration (EC50) of about...