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Christian R S Reis

Explore the profile of Christian R S Reis including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 12
Citations 252
Followers 0
Related Specialties
Molecular Biology
Biochemistry
Parasitology
Top 10 Co-Authors
Osvaldo P de Melo Neto
Mark Carrington
Eden R Freire
Danielle M N Moura
Camila C Xavier
Tamara D da Costa Lima
Antonio M Rezende
Nancy Standart
Ludmila A Assis
Regina C B Q Figueiredo
Published In
Mol Biochem Parasitol
RNA Biol
BMC Genomics
PLoS One
Nucleic Acids Res
Affiliations
Soon will be listed here.
Recent Articles
1.
Distinct mRNA and protein interactomes highlight functional differentiation of major eIF4F-like complexes from
Bezerra M, Moura D, Freire E, Holetz F, Reis C, Monteiro T, et al.
Front Mol Biosci . 2022 Oct; 9:971811. PMID: 36275617
Gene expression in pathogenic protozoans of the family Trypanosomatidae has several novel features, including multiple eIF4F-like complexes involved in protein synthesis. The eukaryotic eIF4F complex, formed mainly by eIF4E and...
2.
Assessment of a recombinant protein from Leishmania infantum as a novel tool for Visceral Leishmaniasis (VL) diagnosis in VL/HIV co-infection cases
Ramos R, Santos W, Magalhaes F, Diniz G, Costa C, de Melo Neto O, et al.
PLoS One . 2021 May; 16(5):e0251861. PMID: 33999968
Visceral Leishmaniasis and HIV-AIDS coinfection (VL/HIV) is considered a life-threatening pathology when undiagnosed and untreated, due to the immunosuppression caused by both diseases. Serological tests largely used for the VL...
3.
A new recombinant F1 antigen as a cost and time-effective tool for plague diagnosis
Tavares D, Bezerra M, Magalhaes F, Cavalcanti T, Xavier C, Leal N, et al.
J Microbiol Methods . 2020 Apr; 172:105903. PMID: 32229265
The Yersinia pestis capsular antigen F1 is widely used in plague laboratory diagnosis. Here, we describe the production of an F1 recombinant protein within reduced time and biosafety requirements. Its...
4.
Phosphorylation and interactions associated with the control of the Leishmania Poly-A Binding Protein 1 (PABP1) function during translation initiation
de Melo Neto O, da Costa Lima T, Merlo K, Romao T, Rocha P, Assis L, et al.
RNA Biol . 2018 Mar; 15(6):739-755. PMID: 29569995
The Poly-A Binding Protein (PABP) is a conserved eukaryotic polypeptide involved in many aspects of mRNA metabolism. During translation initiation, PABP interacts with the translation initiation complex eIF4F and enhances...
5.
The unique Leishmania EIF4E4 N-terminus is a target for multiple phosphorylation events and participates in critical interactions required for translation initiation
de Melo Neto O, da Costa Lima T, Xavier C, Nascimento L, Romao T, Assis L, et al.
RNA Biol . 2015 Sep; 12(11):1209-21. PMID: 26338184
The eukaryotic initiation factor 4E (eIF4E) recognizes the mRNA cap structure and, together with eIF4G and eIF4A, form the eIF4F complex that regulates translation initiation in eukaryotes. In trypanosomatids, 2...
6.
Two related trypanosomatid eIF4G homologues have functional differences compatible with distinct roles during translation initiation
Moura D, Reis C, Xavier C, da Costa Lima T, Lima R, Carrington M, et al.
RNA Biol . 2015 Apr; 12(3):305-19. PMID: 25826663
In higher eukaryotes, eIF4A, eIF4E and eIF4G homologues interact to enable mRNA recruitment to the ribosome. eIF4G acts as a scaffold for these interactions and also interacts with other proteins...
7.
The translation initiation complex eIF3 in trypanosomatids and other pathogenic excavates--identification of conserved and divergent features based on orthologue analysis
Rezende A, Assis L, Nunes E, da Costa Lima T, Marchini F, Freire E, et al.
BMC Genomics . 2014 Dec; 15:1175. PMID: 25539953
Background: The initiation of translation in eukaryotes is supported by the action of several eukaryotic Initiation Factors (eIFs). The largest of these is eIF3, comprising of up to thirteen polypeptides...
8.
The eIF4E subunits of two distinct trypanosomatid eIF4F complexes are subjected to differential post-translational modifications associated to distinct growth phases in culture
Pereira M, Malvezzi A, Nascimento L, da Costa Lima T, Alves V, Palma M, et al.
Mol Biochem Parasitol . 2013 Jul; 190(2):82-6. PMID: 23867205
The eukaryotic eIF4F complex, the cap binding complex, functions during translation initiation through interactions mediated by its three subunits (eIF4E, eIF4G and eIF4A), other initiation factors and the ribosome. In...
9.
The four trypanosomatid eIF4E homologues fall into two separate groups, with distinct features in primary sequence and biological properties
Freire E, Dhalia R, Moura D, da Costa Lima T, Lima R, Reis C, et al.
Mol Biochem Parasitol . 2010 Nov; 176(1):25-36. PMID: 21111007
Translation initiation in eukaryotes requires eIF4E, the cap binding protein, which mediates its function through an interaction with the scaffolding protein eIF4G, as part of the eIF4F complex. In trypanosomatids,...
10.
Functional characterization of three leishmania poly(a) binding protein homologues with distinct binding properties to RNA and protein partners
da Costa Lima T, Moura D, Reis C, Vasconcelos J, Ellis L, Carrington M, et al.
Eukaryot Cell . 2010 Aug; 9(10):1484-94. PMID: 20675580
Trypanosomatid protozoans are reliant on posttranscriptional processes to control gene expression. Regulation occurs at the levels of mRNA processing, stability, and translation, events that may require the participation of the...