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Christian Goritz

Explore the profile of Christian Goritz including associated specialties, affiliations and a list of published articles. Areas
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Articles 30
Citations 2353
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Recent Articles
1.
Grommisch D, Lund H, Eenjes E, Julien A, Goritz C, Harris R, et al.
Dev Cell . 2024 Oct; 60(2):320-336.e9. PMID: 39426382
Regionalized disease prevalence is a common feature of the gastrointestinal tract. Herein, we employed regionally resolved Smart-seq3 single-cell sequencing, generating a comprehensive cell atlas of the adult mouse esophagus. Characterizing...
2.
Hachemi Y, Perrin S, Ethel M, Julien A, Vettese J, Geisler B, et al.
Bone Res . 2024 Sep; 12(1):56. PMID: 39341816
Musculoskeletal traumatic injuries (MTI) involve soft tissue lesions adjacent to a bone fracture leading to fibrous nonunion. The impact of MTI on the inflammatory response to fracture and on the...
3.
Amoedo-Leite C, Parv K, Testini C, Herrera-Hidalgo C, Xu F, Giraud A, et al.
Nat Cardiovasc Res . 2024 Aug; 3(6):685-700. PMID: 39196227
Sterile inflammation after injury is important for tissue restoration. In injured human and mouse tissues, macrophages were recently found to accumulate perivascularly. This study investigates if macrophages adopt a mural...
4.
Holl D, Hau W, Julien A, Banitalebi S, Kalkitsas J, Savant S, et al.
Nat Neurosci . 2024 Jun; 27(7):1285-1298. PMID: 38849523
Fibrotic scar tissue formation occurs in humans and mice. The fibrotic scar impairs tissue regeneration and functional recovery. However, the origin of scar-forming fibroblasts is unclear. Here, we show that...
5.
Hachemi Y, Perrin S, Ethel M, Julien A, Vettese J, Geisler B, et al.
bioRxiv . 2024 May; PMID: 38746344
Summary: Hachemi et al. report the immune cell atlas of bone repair revealing macrophages as pro-fibrotic regulators and a therapeutic target for musculoskeletal regeneration. Genetic depletion or pharmacological inhibition of...
6.
Guimaraes E, Dias D, Hau W, Julien A, Holl D, Garcia-Collado M, et al.
Science . 2024 Feb; 383(6683):eade8064. PMID: 38330107
Penile erection is mediated by the corpora cavernosa, a trabecular-like vascular bed that enlarges upon vasodilation, but its regulation is not completely understood. Here, we show that perivascular fibroblasts in...
7.
Lund H, Hunt M, Kurtovic Z, Sandor K, Kagy P, Fereydouni N, et al.
J Exp Med . 2023 Dec; 221(2). PMID: 38117255
In dorsal root ganglia (DRG), macrophages reside close to sensory neurons and have largely been explored in the context of pain, nerve injury, and repair. However, we discovered that most...
8.
Holl D, Goritz C
Am J Physiol Cell Physiol . 2023 Oct; 325(6):C1415-C1420. PMID: 37811731
Recent advancements in human tissue analyses and animal models have revealed that fibrotic scarring is a common response to various lesions in the central nervous system (CNS). Perivascular cells within...
9.
Stenudd M, Sabelstrom H, Llorens-Bobadilla E, Zamboni M, Blom H, Brismar H, et al.
Cell Rep . 2022 Mar; 38(9):110440. PMID: 35235796
Spinal cord ependymal cells display neural stem cell properties in vitro and generate scar-forming astrocytes and remyelinating oligodendrocytes after injury. We report that ependymal cells are functionally heterogeneous and identify...
10.
Dias D, Kalkitsas J, Kelahmetoglu Y, Estrada C, Tatarishvili J, Holl D, et al.
Nat Commun . 2021 Sep; 12(1):5501. PMID: 34535655
Fibrotic scar tissue limits central nervous system regeneration in adult mammals. The extent of fibrotic tissue generation and distribution of stromal cells across different lesions in the brain and spinal...