Chris Todd Hittinger
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Explore the profile of Chris Todd Hittinger including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Feng B, Li Y, Liu H, Steenwyk J, David K, Tian X, et al.
bioRxiv
. 2024 Jun;
PMID: 38895429
Gene gains and losses are a major driver of genome evolution; their precise characterization can provide insights into the origin and diversification of major lineages. Here, we examined gene family...
12.
Zavala B, Dineen L, Fisher K, Opulente D, Harrison M, Wolters J, et al.
bioRxiv
. 2024 Jun;
PMID: 38826271
Codon usage bias, or the unequal use of synonymous codons, is observed across genes, genomes, and between species. The biased use of synonymous codons has been implicated in many cellular...
13.
Harrison M, Ubbelohde E, LaBella A, Opulente D, Wolters J, Zhou X, et al.
Proc Natl Acad Sci U S A
. 2024 Apr;
121(18):e2315314121.
PMID: 38669185
How genomic differences contribute to phenotypic differences is a major question in biology. The recently characterized genomes, isolation environments, and qualitative patterns of growth on 122 sources and conditions of...
14.
Opulente D, LaBella A, Harrison M, Wolters J, Liu C, Li Y, et al.
Science
. 2024 Apr;
384(6694):eadj4503.
PMID: 38662846
Organisms exhibit extensive variation in ecological niche breadth, from very narrow (specialists) to very broad (generalists). Two general paradigms have been proposed to explain this variation: (i) trade-offs between performance...
15.
Rojas J, Hose J, Dutcher H, Place M, Wolters J, Hittinger C, et al.
bioRxiv
. 2024 Apr;
PMID: 38645209
Although implicated as deleterious in many organisms, aneuploidy can underlie rapid phenotypic evolution. However, aneuploidy will only be maintained if the benefit outweighs the cost, which remains incompletely understood. To...
16.
Sun L, David K, Wolters J, Karlen S, Goncalves C, Opulente D, et al.
Mol Biol Evol
. 2024 Feb;
41(4).
PMID: 38415839
Siderophores are crucial for iron-scavenging in microorganisms. While many yeasts can uptake siderophores produced by other organisms, they are typically unable to synthesize siderophores themselves. In contrast, Wickerhamiella/Starmerella (W/S) clade...
17.
David K, Harrison M, Opulente D, LaBella A, Wolters J, Zhou X, et al.
Proc Natl Acad Sci U S A
. 2024 Feb;
121(10):e2316031121.
PMID: 38412132
The Saccharomycotina yeasts ("yeasts" hereafter) are a fungal clade of scientific, economic, and medical significance. Yeasts are highly ecologically diverse, found across a broad range of environments in every biome...
18.
Pontes A, Paraiso F, Liu Y, Limtong S, Jindamorakot S, Jespersen L, et al.
iScience
. 2024 Feb;
27(2):108987.
PMID: 38333711
When grows on mixtures of glucose and galactose, galactose utilization is repressed by glucose, and induction of the gene network only occurs when glucose is exhausted. Contrary to reference alleles,...
19.
Barros K, Mader M, Krause D, Pangilinan J, Andreopoulos B, Lipzen A, et al.
Biotechnol Biofuels Bioprod
. 2024 Feb;
17(1):20.
PMID: 38321504
Background: Cost-effective production of biofuels from lignocellulose requires the fermentation of D-xylose. Many yeast species within and closely related to the genera Spathaspora and Scheffersomyces (both of the order Serinales)...
20.
Chavez C, Groenewald M, Hulfachor A, Kpurubu G, Huerta R, Hittinger C, et al.
FEMS Yeast Res
. 2023 Dec;
24.
PMID: 38142225
The ∼1 200 known species in subphylum Saccharomycotina are a highly diverse clade of unicellular fungi. During its lifecycle, a typical yeast exhibits multiple cell types with various morphologies; these...