Chris S Pridgeon
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Explore the profile of Chris S Pridgeon including associated specialties, affiliations and a list of published articles.
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11
Citations
118
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Recent Articles
1.
Pridgeon C, Airavaara K, Monola J, Jokela A, Palmer D, Yliperttula M, et al.
Sci Rep
. 2024 Oct;
14(1):25189.
PMID: 39448620
Variations in oxygen level affect the phenotype of cells and extracellular vesicles (EVs). Depending on the metabolic oxygen demand of cells, hypoxic cell culture can produce conditions more like those...
2.
Polez R, Huynh N, Pridgeon C, Valle-Delgado J, Harjumaki R, Osterberg M
Mater Today Bio
. 2024 May;
26:101065.
PMID: 38706731
The recent FDA decision to eliminate animal testing requirements emphasises the role of cell models, such as spheroids, as regulatory test alternatives for investigations of cellular behaviour, drug responses, and...
3.
Koivunotko E, Koivuniemi R, Monola J, Harjumaki R, Pridgeon C, Madetoja M, et al.
J Control Release
. 2024 Feb;
368:397-412.
PMID: 38423475
Platelet-rich plasma (PRP) is a source of growth factors, which are implicated in active tissue regeneration. However, after transplantation the efficacy of these bioactive compounds is often diminished due to...
4.
Pridgeon C, Forootan S, Zhang F, Harper N, Palmer D, Weightmann R, et al.
J Stem Cells Regen Med
. 2023 Jun;
19(1):3-13.
PMID: 37366409
Human pluripotent stem cells (hPSCs) are a promising source of somatic cells for clinical applications and disease modelling. However, during culture they accumulate genetic aberrations such as amplification of 20q11.21...
5.
Pridgeon C, Johansson I, Ingelman-Sundberg M
Clin Pharmacol Ther
. 2022 Sep;
112(6):1155.
PMID: 36111792
No abstract available.
6.
Pridgeon C, Johansson I, Ingelman-Sundberg M
Clin Pharmacol Ther
. 2022 Jun;
112(5):1000-1003.
PMID: 35766115
During pharmacotherapy, knowledge about the actual drug and metabolite concentrations in plasma is often critical. Individual dose adjustments can be performed based on pre-emptive genotyping of certain absorption, distribution, metabolism,...
7.
Pridgeon C, Bolhuis D, Milosavljevic F, Manojlovic M, Vegvari A, Gaetani M, et al.
Cells
. 2022 May;
11(10).
PMID: 35626634
The in vivo-relevant phenotype of 3D liver spheroids allows for long-term studies of, e.g., novel mechanisms of chronic drug-induced liver toxicity. Using this system, we present a novel drug-induced stress...
8.
Harjumaki R, Pridgeon C, Ingelman-Sundberg M
Int J Mol Sci
. 2021 Aug;
22(15).
PMID: 34360999
CYP2E1 is one of the fifty-seven cytochrome P450 genes in the human genome and is highly conserved. CYP2E1 is a unique P450 enzyme because its heme iron is constitutively in...
9.
Lynch S, Pridgeon C, Duckworth C, Sharma P, Park B, Goldring C
Biochem J
. 2019 Apr;
476(7):1149-1158.
PMID: 30988136
Adverse drug reactions (ADRs) are the unintended side effects of drugs. They are categorised as either predictable or unpredictable drug-induced injury and may be exhibited after a single or prolonged...
10.
Pridgeon C, Schlott C, Wong M, Heringa M, Heckel T, Leedale J, et al.
Arch Toxicol
. 2018 Jan;
92(2):557-569.
PMID: 29362863
The development of improved, innovative models for the detection of toxicity of drugs, chemicals, or chemicals in cosmetics is crucial to efficiently bring new products safely to market in a...